南非一家儿童医院产碳青霉烯酶肠杆菌科细菌患者使用头孢他啶-阿维巴坦治疗的情况
Ceftazidime-Avibactam Treatment for Carbapenemase-Producing Enterobacterales in a South African Children's Hospital.
机构信息
Medical Microbiology, National Health Laboratory Service, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.
Medical School, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
出版信息
J Pediatric Infect Dis Soc. 2024 Nov 4;13(10):541-546. doi: 10.1093/jpids/piae087.
This study describes ceftazidime-avibactam use in 17 young children from a resource-constrained country, where intra-abdominal infection was common. All-cause mortality was 53%. Earlier initiation, dose optimization, recording infusion times, and reviewing the need for additional antibiotics were identified as easy-to-implement-antimicrobial-stewardship interventions.
本研究描述了在资源有限的国家中 17 名幼儿使用头孢他啶-阿维巴坦的情况，这些儿童的常见感染部位为腹腔。全因死亡率为 53%。研究认为，早期启动、优化剂量、记录输注时间以及评估是否需要额外使用抗生素是易于实施的抗菌药物管理干预措施。
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