仓鼠经腹腔或皮下接种实验性羊瘙痒病后的视网膜变性
Retinal degeneration in experimental scrapie after intraperitoneal or subcutaneous inoculation of hamsters.
作者信息
Buyukmihci N, Goehring-Harmon F, Marsh R F
出版信息
Exp Neurol. 1985 May;88(2):461-6. doi: 10.1016/0014-4886(85)90207-9.
PMID:3921398
Abstract
Hamsters injected intraperitoneally or subcutaneously with the scrapie agent developed photoreceptor degeneration. The degree of degeneration did not correlate well with infectivity titers of retinal tissue or stage of clinical encephalopathy, and was not as great as seen in intracerebrally injected animals. We conclude that retinal degeneration is universal in hamsters experimentally inoculated with the scrapie agent regardless of the route of inoculation.
摘要
经腹腔内或皮下注射瘙痒病病原体的仓鼠出现了光感受器退化。退化程度与视网膜组织的感染性滴度或临床脑病阶段的相关性不佳，且不如脑内注射动物所见的严重。我们得出结论，无论接种途径如何，在实验性接种瘙痒病病原体的仓鼠中，视网膜退化是普遍存在的。
相似文献
1
Retinal degeneration in experimental scrapie after intraperitoneal or subcutaneous inoculation of hamsters.仓鼠经腹腔或皮下接种实验性羊瘙痒病后的视网膜变性
Exp Neurol. 1985 May;88(2):461-6. doi: 10.1016/0014-4886(85)90207-9.
2
Neural pathogenesis of experimental scrapie after intraocular inoculation of hamsters.仓鼠眼内接种后实验性瘙痒病的神经发病机制
Exp Neurol. 1983 Aug;81(2):396-406. doi: 10.1016/0014-4886(83)90271-6.
3
Replication of the scrapie agent in ocular neural tissues.瘙痒病病原体在眼部神经组织中的复制。
Proc Natl Acad Sci U S A. 1980 Feb;77(2):1169-71. doi: 10.1073/pnas.77.2.1169.
4
Replication of scrapie prions in hamster eyes precedes retinal degeneration.仓鼠眼中羊瘙痒病朊病毒的复制先于视网膜变性。
Ophthalmic Res. 1986;18(4):230-5. doi: 10.1159/000265439.
5
Asymmetry of retinal lesions in experimental scrapie after intracerebral inoculation of hamsters.仓鼠脑内接种实验性瘙痒病后视网膜病变的不对称性。
Exp Neurol. 1985 Jan;87(1):172-6. doi: 10.1016/0014-4886(85)90143-8.
6
Retinal degeneration during clinical scrapie encephalopathy in hamsters.仓鼠临床瘙痒病脑病期间的视网膜变性。
J Comp Neurol. 1982 Feb 20;205(2):153-60. doi: 10.1002/cne.902050206.
7
Progressive retinal degeneration in scrapie-infected hamsters: a light and electron microscopic analysis.瘙痒病感染仓鼠的进行性视网膜变性：光镜和电镜分析
Lab Invest. 1981 Jan;44(1):34-42.
8
Photoreceptor degeneration during infection with various strains of the scrapie agent in hamsters.仓鼠感染不同毒株瘙痒病病原体期间的光感受器变性。
Exp Neurol. 1987 Jul;97(1):201-6. doi: 10.1016/0014-4886(87)90294-9.
9
Photoreceptor degeneration in experimental transmissible mink encephalopathy of hamsters.仓鼠实验性可传播水貂脑病中的光感受器变性
Exp Neurol. 1987 Jun;96(3):727-31. doi: 10.1016/0014-4886(87)90233-0.
10
Ocular effects of scrapie agent in hamsters: preliminary observations.仓鼠中瘙痒病病原体的眼部效应：初步观察
Invest Ophthalmol Vis Sci. 1977 Apr;16(4):319-24.
引用本文的文献
1
Clinical, electroretinographic and histomorphometric evaluation of the retina in sheep with natural scrapie.自然感染瘙痒病绵羊的临床、视网膜电图和组织形态计量学评估。
BMC Vet Res. 2011 Jun 6;7:25. doi: 10.1186/1746-6148-7-25.
2
A case of Creutzfeldt-Jakob disease related to familial retinitis pigmentosa patients.1例与家族性视网膜色素变性患者相关的克雅氏病病例。
Eur J Epidemiol. 1988 Mar;4(1):55-9. doi: 10.1007/BF00152693.
Zotero 插件