仓鼠脑内接种实验性瘙痒病后视网膜病变的不对称性。
Asymmetry of retinal lesions in experimental scrapie after intracerebral inoculation of hamsters.
作者信息
Buyukmihci N, Goehring-Harmon F, Marsh R F
出版信息
Exp Neurol. 1985 Jan;87(1):172-6. doi: 10.1016/0014-4886(85)90143-8.
PMID:4038487
Abstract
Hamsters injected into the right cerebral hemisphere with the scrapie agent developed retinal lesions to a greater extent in the contralateral than in the ipsilateral eye. This asymmetry was evident during the incubation period as well as during the clinical encephalopathy. The results explain much of the variation in the degree of retinal disease seen earlier at specific times after inoculation. Moreover, they strengthen the hypothesis that scrapie spreads via neurons.
摘要
向右侧大脑半球注射瘙痒病病原体的仓鼠，其对侧眼睛比同侧眼睛出现视网膜病变的程度更严重。这种不对称在潜伏期以及临床脑病期都很明显。这些结果解释了接种后特定时间点早期所见视网膜疾病程度变化的很大一部分原因。此外，它们强化了瘙痒病通过神经元传播的假说。
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