Buyukmihci N, Rorvik M, Marsh R F
Proc Natl Acad Sci U S A. 1980 Feb;77(2):1169-71. doi: 10.1073/pnas.77.2.1169.
Optic nerves and retinas removed from hamsters experimentally inoculated with the scrapie agent contain a high titer of infectivity. Ophthalmoscopic examination of these animals revealed gross lesions of retinopathy as early as 3 weeks before the onset of clinical signs of brain degeneration. These results suggest that the scrapie agent may spread centrifugally in nerve fibers after intracerebral inoculation and that the scrapie-associated retinopathy seen in hamsters is directly induced by the agent rather than the result of retrograde degeneration from central neural damage.
从实验接种了瘙痒病病原体的仓鼠身上取出的视神经和视网膜含有高滴度的传染性。对这些动物的检眼镜检查显示，早在脑部退化临床症状出现前3周就有视网膜病变的明显损伤。这些结果表明，瘙痒病病原体在脑内接种后可能沿神经纤维离心扩散，并且仓鼠身上出现的与瘙痒病相关的视网膜病变是由该病原体直接诱发的，而非中枢神经损伤逆行变性的结果。
