Zhang Zichuan, Zhang Qian, Xue Yi, Chen Guang, Wu Zhongyin, Fang Huiqing
Department of Stomatology, the 980th Hospital of the Chinese People's Liberation Army Joint Logistics Support Force, Shijiazhuang.
State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Department of General Dentistry and Emergency, School of Stomatology, Air Force Medical University, Xi'an, PR China.
Medicine (Baltimore). 2019 Jan;98(3):e14039. doi: 10.1097/MD.0000000000014039.
Recurrent aphthous stomatitis (RAS) is one of the most common inflammatory ulcerative conditions of oral cavity with uncertain etiology. Several studies have reported that oxidative stress may be associated with RAS. The aim of this study was to compare the serum levels of total antioxidant status (TAS), nitric oxide (NO) and nitric oxide synthase (NOS) in minor RAS (MiRAS) patients with healthy individuals and determine the possible association of MiRAS with the 3 physiological parameters mentioned above.
Ninety patients with idiopathic MiRAS and 90 race-, age- and sex-matched healthy individuals were included in this study. All these subjects were allocated to 3 groups: MiRAS patients in the active stage (Group A); the same MiRAS patients in Group A in the inactive stage (Group B); healthy individuals without MiRAS (Group C). Serum levels of TAS, NO and NOS were determined by the spectrophotometric method. Independent sample t test and paired t test were performed for statistical evaluation.
Serum TAS level of Group A was significantly decreased than that of Group C, whereas the serum level of NO was significantly higher in Group A as compared to Group C (P < .05). The serum levels of TAS and NO in Group B were no significant differences when compared with those in Group A or Group C. No significant differences in NOS activities were also found between the 3 groups (P > .05).
MiRAS is associated with decreased TAS and increased NO levels, but NOS may not play an important role in the aetiopathogenesis.
复发性阿弗他口炎（RAS）是口腔最常见的炎性溃疡性疾病之一，病因不明。多项研究报道氧化应激可能与RAS有关。本研究旨在比较轻型RAS（MiRAS）患者与健康个体血清中总抗氧化状态（TAS）、一氧化氮（NO）和一氧化氮合酶（NOS）水平，并确定MiRAS与上述3种生理参数之间可能存在的关联。
本研究纳入90例特发性MiRAS患者和90例种族、年龄和性别相匹配的健康个体。所有这些受试者被分为3组：活动期MiRAS患者（A组）；A组中处于非活动期的同一MiRAS患者（B组）；无MiRAS的健康个体（C组）。采用分光光度法测定血清TAS、NO和NOS水平。进行独立样本t检验和配对t检验进行统计学评估。
A组血清TAS水平显著低于C组，而A组血清NO水平显著高于C组（P<0.05）。B组血清TAS和NO水平与A组或C组相比无显著差异。3组之间NOS活性也无显著差异（P>0.05）。
MiRAS与TAS降低和NO水平升高有关，但NOS可能在发病机制中不起重要作用。
