噬菌体免疫沉淀测序在诊断1例吉兰-巴雷综合征潜在病因肠道病毒D68中的临床应用
Clinical Application of Phage Immunoprecipitation Sequencing to Diagnose Enterovirus D68 as the Underlying Etiology in a Case of Guillain-Barré Syndrome.
作者信息
Li Fang Fang, Faber Alison, Caleta Jessica M, Goldfarb David M, Sekirov Inna, Prystajecky Natalie A, Srigley Jocelyn A, Mishaal Ram, Jassem Agatha N
机构信息
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
出版信息
J Infect Dis. 2025 Feb 20;231(2):490-494. doi: 10.1093/infdis/jiae411.
Abstract
Guillain-Barré syndrome (GBS) is an acute peripheral neuropathy often preceded by respiratory or gastrointestinal infections, though molecular testing of cerebrospinal fluid is often inconclusive. In a recent case of severe pediatric GBS in British Columbia, Canada, we detected cerebrospinal fluid antibodies against enterovirus D to link GBS with prior enterovirus D68 respiratory infection.
摘要
吉兰-巴雷综合征（GBS）是一种急性周围神经病变，通常在呼吸道或胃肠道感染后出现，尽管脑脊液的分子检测结果往往不明确。在加拿大不列颠哥伦比亚省最近一例严重的儿童GBS病例中，我们检测到脑脊液中存在抗肠道病毒D的抗体，从而将GBS与先前的肠道病毒D68呼吸道感染联系起来。
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