Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, 675 Nelson Rising Lane, NS212A, Campus Box 3206, San Francisco, CA 94158, USA.
Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, 675 Nelson Rising Lane, NS212A, Campus Box 3206, San Francisco, CA 94158, USA.
Neurol Clin. 2018 Nov;36(4):687-703. doi: 10.1016/j.ncl.2018.07.004.
Neuroinfectious diseases continue to cause morbidity and mortality worldwide, with many emerging or reemerging infections resulting in neurologic sequelae. Careful clinical evaluation coupled with appropriate laboratory investigations still forms the bedrock for making the correct etiologic diagnosis and implementing appropriate management. The treating physician needs to understand the individual test characteristics of each of the many conventional candidate-based diagnostics: culture, pathogen-specific polymerase chain reaction, antigen, antibody tests, used to diagnose the whole array of neuroinvasive infections. In addition, there is a growing need for more comprehensive, agnostic testing modalities that can identify a diversity of infections with a single assay.
神经感染性疾病在全球范围内仍持续导致发病率和死亡率，许多新发或再发感染导致神经系统后遗症。仔细的临床评估加上适当的实验室检查仍然是做出正确病因诊断和实施适当治疗的基础。治疗医生需要了解用于诊断各种神经侵袭性感染的许多传统候选物诊断方法的个体检测特点：培养、病原体特异性聚合酶链反应、抗原、抗体检测。此外，人们越来越需要更全面、通用的检测方式，以便能够通过单一检测来识别多种感染。
