Knuth U A, Nieschlag E
J Endocrinol Invest. 1985 Feb;8(1):55-7. doi: 10.1007/BF03350640.
The dose-response of serum prolactin (PRL) values to different doses of naloxone (NAL) in rats is bellshaped. To test the effect of different doses of NAL on serum FSH, LH and PRL in humans these hormones were measured in 4 male volunteers after subject blind infusion of 0.02, 0.2 and 0.5 mg/kg NAL in random order. A saline infusion served as control. On each occasion an adjusted volume of 100 ml was infused within 10 min via an antecubital vein. Consequently blood samples were taken every 15 min for 4 h. To compare the response to the different treatments for each hormone the average of an individual's hormone values (4 x 16) was set to 100%. Values at each timepoint were expressed in relation to the volunteer's mean. The means and SE of hormone values set to 100% were: LH = 5.7 +/- 0.7 ng/ml; FSH = 3.1 +/- 1.0 ng/ml and PRL = 186 +/- 37 muU/ml. NAL infusion did not affect FSH levels at any dose level. No overall effect of NAL on PRL levels was detectable. There was a significant difference in LH values between saline control and NAL infusions, although no significant difference could be detected between different doses of NAL. Higher doses of NAL merely sustained LH levels for a longer time period. Based on the data presented a short test is suggested for screening patients under different pathophysiological conditions for involvement of endogenous opioids in the regulation of LH secretion.
大鼠血清催乳素（PRL）值对不同剂量纳洛酮（NAL）的剂量反应呈钟形。为了测试不同剂量的NAL对人体血清促卵泡激素（FSH）、促黄体生成素（LH）和PRL的影响，对4名男性志愿者进行了盲法输注，随机给予0.02、0.2和0.5mg/kg的NAL，以生理盐水输注作为对照。每次通过肘前静脉在10分钟内输注100ml的调整体积。因此，在4小时内每隔15分钟采集一次血样。为了比较每种激素对不同治疗的反应，将个体激素值的平均值（4×16）设定为100%。每个时间点的值相对于志愿者的平均值表示。设定为100%的激素值的平均值和标准误为：LH = 5.7±0.7ng/ml；FSH = 3.1±1.0ng/ml；PRL = 186±37mU/ml。在任何剂量水平下，NAL输注均不影响FSH水平。未检测到NAL对PRL水平的总体影响。生理盐水对照和NAL输注之间的LH值存在显著差异，尽管不同剂量的NAL之间未检测到显著差异。较高剂量的NAL只是使LH水平维持更长时间。根据所提供的数据，建议进行一项简短测试，以筛查处于不同病理生理状态的患者，看内源性阿片类物质是否参与LH分泌的调节。
