Kreminger Judith, Iby Johannes, Rokitansky Stephanie, Stino Heiko, Niederleithner Michael, Schlegl Thomas, Drexler Wolfgang, Schmoll Tilman, Leitgeb Rainer, Pollreisz Andreas, Schmidt-Erfurth Ursula, Sacu Stefan
Vienna Clinical Trial Center (VTC), Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.
Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.
Can J Ophthalmol. 2025 Jun;60(3):e443-e450. doi: 10.1016/j.jcjo.2024.08.007. Epub 2024 Aug 29.
To investigate the localization, distribution, and type of central microaneurysms (MAs) and their relationship with retinal vascular alterations in patients with retinal vein occlusion (RVO).
In this cross-sectional study, ultra-widefield color fundus photography (UWF-CF), standard and single-capture 65° widefield (WF) optical coherence tomography angiography (OCTA) were performed in consecutive patients with RVO treated at the Department of Ophthalmology and Optometry, Medical University of Vienna. UWF-CF, en face and B-Scans in 6 mm × 6 mm OCTA were examined for detection of MAs. Nonperfusion areas (NPA) and collateral vessels (CV) were evaluated on WF-OCTA, ghost vessels (GV), and tortuous vessels (TV) on UWF-CF.
One-hundred-and-twelve patients were included in the study, and data from 59 eyes of 59 patients with disease duration longer than 3 months, good image quality, and without relevant ocular comorbidities were eligible for statistical analysis. Fifty-six of 59 (94.9%) patients were previously treated with anti-vascular endothelial growth factor agents for macular edema, 31 of 59 (52.5%) patients presented with MAs in the central 6 mm and 60 MAs were found in total using multimodal imaging. There was no statistically significant difference in the greatest diameter of fluid-associated versus non-fluid-associated MAs (p = 0.53). Eyes with MAs were associated with CV, TV, and GV (χ-test; p < 0.001, p = 0.0498, and p = 0.001). Median NPA was 27.3 mm (quartiles 1.3-62.8 mm) in eyes with MAs and 0 mm (quartiles 0-36.2 mm) in eyes without MAs (Mann-Whitney-U-test; p = 0.018).
MAs were associated with extensive NPA, the presence of CV, GV, and TV. There was no correlation between the diameter of the MA and the adjacent intraretinal fluid in our predominantly pretreated RVO study patients.
研究视网膜静脉阻塞（RVO）患者中央微动脉瘤（MA）的定位、分布、类型及其与视网膜血管改变的关系。
在这项横断面研究中，对维也纳医科大学眼科与验光科连续收治的RVO患者进行超广角彩色眼底照相（UWF-CF）、标准和单次采集65°宽视野（WF）光学相干断层扫描血管造影（OCTA）检查。在UWF-CF、6mm×6mm OCTA的正面和B扫描中检查MA的检测情况。在WF-OCTA上评估无灌注区（NPA）和侧支血管（CV），在UWF-CF上评估幽灵血管（GV）和迂曲血管（TV）。
112例患者纳入研究，59例疾病持续时间超过3个月、图像质量良好且无相关眼部合并症患者的59只眼的数据符合统计分析要求。59例患者中有56例（94.9%）曾接受抗血管内皮生长因子药物治疗黄斑水肿，59例患者中有31例（52.5%）在中央6mm范围内出现MA，使用多模态成像共发现60个MA。与液体相关的MA和非液体相关的MA的最大直径无统计学显著差异（p = 0.53）。有MA的眼与CV、TV和GV相关（χ检验；p < 0.001，p = 0.0498，p = 0.001）。有MA的眼中位NPA为27.3mm（四分位数1.3 - 62.8mm），无MA的眼中位NPA为0mm（四分位数0 - 36.2mm）（Mann-Whitney-U检验；p = 0.018）。
MA与广泛的NPA、CV、GV和TV的存在相关。在我们以接受过治疗的RVO研究患者为主的研究中，MA的直径与相邻视网膜内液之间无相关性。
