Centre for Interdisciplinary Sciences, JIS Institute of Advanced Studies and Research (JISIASR) Kolkata, JIS University, GP Block, Salt Lake, Sector-5, WB-700091, India.
School of Advanced Materials, Green Energy and Sensor Systems, Indian Institute of Engineering Science and Technology, Shibpur, Howrah 711103, West Bengal, India.
Int J Biol Macromol. 2024 Nov;279(Pt 2):135213. doi: 10.1016/j.ijbiomac.2024.135213. Epub 2024 Aug 30.
Several advances in skin tissue engineering have been made to restore skin damage, facilitating wound healing. Bacterial cellulose (BC), a naturally occurring polymer, has gained attention as a potential material in wound healing due to its unique physical and biological properties. In recent years, with the advent of 3D bio-printing technology, new avenues have opened for fabricating customized wound dressings and scaffolds for tissue engineering purposes. The existing literature in this field mainly focuses on the ways of modifications of bacterial cellulose to make it printable. Still, the applicability of 3D printed scaffolds for wound healing needs to be explored more. This review article focuses on the current research on using 3D-printed BC for skin regeneration, including its production methods and physical and biological properties, making it a better choice than traditional dressings. Furthermore, it also highlights the limitations and future directions for using BC in wound healing and tissue engineering applications. This review provides a comprehensive and up-to-date exploration of the applications of 3D-printed BC in wound healing, drawing insights from pre-existing studies and emphasizing patient compliance, clinical outcomes, and economic viability.
近年来,随着 3D 生物打印技术的出现,为制造定制化的伤口敷料和组织工程支架开辟了新途径。该领域的现有文献主要集中在对细菌纤维素进行修饰使其可打印的方法上。然而,3D 打印支架在伤口愈合中的适用性仍需进一步探索。本文主要聚焦于使用 3D 打印细菌纤维素进行皮肤再生的研究,包括其生产方法、物理和生物学性能,使其成为比传统敷料更好的选择。此外,还强调了细菌纤维素在伤口愈合和组织工程应用中的局限性和未来发展方向。本文综述提供了对 3D 打印细菌纤维素在伤口愈合中的应用的全面和最新探索,从现有研究中汲取见解,并强调了患者依从性、临床结果和经济可行性。