Department of Biomedical Engineering, University of Memphis, Memphis, TN, USA; Department of Mechanical Engineering, École de Technologie Supérieure, Montreal, Canada; University of Montreal Hospital Research Centre (CRCHUM), Montreal, Canada.
Centre for Commercialization of Regenerative Medicine (CCRM), Toronto, Ontario, Canada.
Int J Biol Macromol. 2024 May;266(Pt 1):131207. doi: 10.1016/j.ijbiomac.2024.131207. Epub 2024 Mar 28.
This review investigates the most recent advances in personalized 3D-printed wound dressings and skin scaffolding. Skin is the largest and most vulnerable organ in the human body. The human body has natural mechanisms to restore damaged skin through several overlapping stages. However, the natural wound healing process can be rendered insufficient due to severe wounds or disturbances in the healing process. Wound dressings are crucial in providing a protective barrier against the external environment, accelerating healing. Although used for many years, conventional wound dressings are neither tailored to individual circumstances nor specific to wound conditions. To address the shortcomings of conventional dressings, skin scaffolding can be used for skin regeneration and wound healing. This review thoroughly investigates polysaccharides (e.g., chitosan, Hyaluronic acid (HA)), proteins (e.g., collagen, silk), synthetic polymers (e.g., Polycaprolactone (PCL), Poly lactide-co-glycolic acid (PLGA), Polylactic acid (PLA)), as well as nanocomposites (e.g., silver nano particles and clay materials) for wound healing applications and successfully 3D printed wound dressings. It discusses the importance of combining various biomaterials to enhance their beneficial characteristics and mitigate their drawbacks. Different 3D printing fabrication techniques used in developing personalized wound dressings are reviewed, highlighting the advantages and limitations of each method. This paper emphasizes the exceptional versatility of 3D printing techniques in advancing wound healing treatments. Finally, the review provides recommendations and future directions for further research in wound dressings.
这篇综述探讨了个性化 3D 打印创面敷料和皮肤支架的最新进展。皮肤是人体最大和最脆弱的器官。人体有通过几个重叠阶段自然修复受损皮肤的机制。然而,由于严重的创伤或愈合过程的干扰,自然的伤口愈合过程可能会不足。创面敷料在提供抵御外部环境的保护屏障、加速愈合方面至关重要。尽管多年来一直使用传统的创面敷料,但它们既不能针对个体情况进行定制,也不能针对创面状况进行定制。为了解决传统敷料的缺点,可以使用皮肤支架来进行皮肤再生和伤口愈合。本综述全面研究了多糖(如壳聚糖、透明质酸(HA))、蛋白质(如胶原蛋白、丝)、合成聚合物(如聚己内酯(PCL)、聚乳酸-共-羟基乙酸(PLGA)、聚乳酸(PLA))以及用于伤口愈合应用的纳米复合材料(如银纳米颗粒和粘土材料)和成功的 3D 打印创面敷料。它讨论了结合各种生物材料以增强它们的有益特性和减轻它们的缺点的重要性。综述了用于开发个性化创面敷料的不同 3D 打印制造技术,突出了每种方法的优点和局限性。本文强调了 3D 打印技术在推进伤口治疗方面的卓越多功能性。最后,综述为创面敷料的进一步研究提供了建议和未来方向。
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