Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Clinical Research Unit, Royal Sussex County Hospital, University Hospitals Sussex NHS, Foundation Trust, Brighton, UK.
Amyotroph Lateral Scler Frontotemporal Degener. 2024 Nov;25(7-8):702-707. doi: 10.1080/21678421.2024.2384992. Epub 2024 Sep 1.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the gradual death of motor neurons in the brain and spinal cord, leading to fatal paralysis. Socioeconomic status (SES) is a measure of an individual's shared economic and social status, which has been shown to have an association with health outcomes. Understanding the impact of SES on health conditions is crucial, as it can influence and be influenced by health-related variables. The role of socioeconomic status in influencing the risk and progression of ALS has not been established, and understanding the various factors that impact ALS is important in developing strategies for treatment and prevention. To investigate this relationship, we recruited 413 participants with definite, probable, or possible ALS according to the El Escorial criteria, from three tertiary centers in London, Sheffield, and Birmingham. Logistic regression was used to examine the association between case-control status, socioeconomic criteria, and ALS risk. Linear regression was used to examine the association between age of onset and socioeconomic variables. Two sensitivity analyses were performed, one using an alternative occupational classifier, and the other using Mendelian Randomization analysis to examine association. There was no significant relationship between any variables and ALS risk. We found an inverse relationship between mean lifetime salary and age of ALS onset (Beta = -0.157, = 0.011), but no effect of education or occupation on the age of onset. The finding was confirmed in both sensitivity analyses and in Mendelian Randomization. We find that a higher salary is associated with a younger age of ALS onset taking into account sex, occupation, years of education, and clinical presentation.
肌萎缩侧索硬化症（ALS）是一种神经退行性疾病，其特征是大脑和脊髓中的运动神经元逐渐死亡，导致致命性瘫痪。社会经济地位（SES）是衡量个人共同经济和社会地位的指标，已显示与健康结果有关。了解 SES 对健康状况的影响至关重要，因为它可以影响和被与健康相关的变量所影响。SES 对 ALS 风险和进展的影响作用尚未确定，了解影响 ALS 的各种因素对于制定治疗和预防策略很重要。为了研究这种关系，我们根据埃尔埃斯科里亚尔标准，从伦敦、谢菲尔德和伯明翰的三个三级中心招募了 413 名明确、可能或可能的 ALS 患者。使用逻辑回归检查病例对照状态、社会经济标准与 ALS 风险之间的关联。使用线性回归检查发病年龄与社会经济变量之间的关联。进行了两次敏感性分析，一次使用替代职业分类器，另一次使用孟德尔随机化分析来检查关联。没有发现任何变量与 ALS 风险之间存在显著关系。我们发现平均终生工资与 ALS 发病年龄之间呈负相关（Beta=-0.157，P=0.011），但教育或职业与发病年龄之间没有关系。这一发现得到了两种敏感性分析和孟德尔随机化分析的证实。我们发现，在考虑到性别、职业、受教育年限和临床表现后，较高的工资与 ALS 发病年龄较年轻有关。
