School of Food and Biological Engineering, Hefei University of Technology, 420 Feicui Road, Hefei, Anhui 230601, PR China; Engineering Research Center of Bio-process, Ministry of Education, Hefei University of Technology, 420 Feicui Road, Hefei, Anhui 230601, PR China.
School of Food and Biological Engineering, Hefei University of Technology, 420 Feicui Road, Hefei, Anhui 230601, PR China; Engineering Research Center of Bio-process, Ministry of Education, Hefei University of Technology, 420 Feicui Road, Hefei, Anhui 230601, PR China.
Int J Biol Macromol. 2024 Nov;279(Pt 2):135181. doi: 10.1016/j.ijbiomac.2024.135181. Epub 2024 Aug 30.
Liver cancer is the third leading cause of cancer death, with high incidence and poor treatment effect. In recent years, polysaccharides have attracted more and more attention in the research field of anti-liver cancer because of their high efficiency, low toxicity, good biocompatibility, wide sources and low cost. Polysaccharides have been proven to have good anti-liver cancer activity. In this paper, the pathways and molecular mechanisms of polysaccharides against liver cancer were reviewed in detail. Polysaccharides exert anti-liver cancer activity by blocking cell cycle, inducing apoptosis, regulating immunity, inhibiting cancer cell metastasis, inhibiting tumor angiogenesis and so on. The primary structure and chain conformation of polysaccharides have an important influence on their anti-liver cancer activity. Structural modification enhanced the anti-liver cancer activity of polysaccharides. Polysaccharides have good attenuated and synergistic effects on chemotherapy drugs. Polysaccharides can be used as functional carriers to construct intelligent nano drug delivery systems (DDS) targeting liver cancer. This review can provide theoretical support for the further development and application of polysaccharides in the field of anti-liver cancer, and provide theoretical reference and clues for relevant researchers in food, nutrition, medicine and other fields.
肝癌是癌症死亡的第三大主要原因，其发病率高，治疗效果差。近年来，由于多糖具有高效、低毒、良好的生物相容性、来源广泛、成本低等特点，在抗肝癌研究领域越来越受到关注。多糖已被证明具有良好的抗肝癌活性。本文详细综述了多糖防治肝癌的作用途径和分子机制。多糖通过阻断细胞周期、诱导细胞凋亡、调节免疫、抑制癌细胞转移、抑制肿瘤血管生成等途径发挥抗肝癌作用。多糖的一级结构和链构象对其抗肝癌活性有重要影响。结构修饰增强了多糖的抗肝癌活性。多糖对化疗药物具有良好的减毒增效作用。多糖可作为功能载体构建针对肝癌的智能纳米药物传递系统（DDS）。该综述可为多糖在抗肝癌领域的进一步开发和应用提供理论支持，并为食品、营养、医学等相关领域的研究人员提供理论参考和线索。
