Cozzens J W, Cerullo L J
Neurosurgery. 1985 Apr;16(4):449-53.
The carbon dioxide laser has recently received clinical acceptance in neurosurgical practice. There are, however, few studies reported in the neurosurgical literature, either clinical or experimental, concerning its safety or efficacy on a physiological level by comparison to a more conventional tool. This study is not a description of a surgical technique, but is rather a basic physiological comparison of two surgical instruments. In this study, 11 cats were pretreated with the protein-bound dye, Evans blue. A corticotomy was performed in one hemisphere with the carbon dioxide laser and in the other with a microbipolar coagulator and a sharp blade. The subsequent extravasation of dye was presumed to be proportional to the amount of blood-brain barrier disruption associated with each lesion. When effective power settings for the two devices were compared, the laser lesions had significantly less extravasation of blue dye. This indicated that there was less damage to the blood-brain barrier surrounding laser corticotomy than surrounding conventional bipolar coagulation and sharp dissection at comparable power settings for each modality.
二氧化碳激光最近已在神经外科手术实践中获得临床认可。然而，与更传统的工具相比，神经外科文献中无论是临床还是实验方面，关于其在生理层面的安全性或有效性的研究报道很少。本研究并非对一种手术技术的描述，而是对两种手术器械的基本生理比较。在本研究中，11只猫预先用蛋白结合染料伊文思蓝进行处理。在一个半球用二氧化碳激光进行皮质切开术，在另一个半球用微型双极电凝器和锋利刀片进行皮质切开术。随后染料的外渗被认为与每个病变相关的血脑屏障破坏量成比例。当比较两种设备的有效功率设置时，激光损伤处蓝色染料的外渗明显较少。这表明在每种方式的可比功率设置下，与传统双极电凝和锐性解剖周围的血脑屏障相比，激光皮质切开术周围的血脑屏障损伤较小。
