Department of Microbiology, Meiji Pharmaceutical University.
Med Mycol J. 2024;65(3):49-57. doi: 10.3314/mmj.24.004.
Candida albicans, the most common pathogenic fungus, can form biofilms on the surface of medical devices and often causes bloodstream infections. Biofilms have a complex structure composed of microorganisms and a surrounding extracellular matrix. Biofilms are difficult to treat because they are resistant to antifungal drugs and the host environment. Nearly one in four patients with candidemia have a polymicrobial infection. These polymicrobial biofilms, especially those comprising cross-kingdom species of fungi and bacteria, can lead to long hospital stays and high mortality rates. This review outlines the unique interactions of dual-species biofilms with Candida albicans and the clinically important bacteria Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli.
白色念珠菌是最常见的致病性真菌，可在医疗器械表面形成生物膜，常引起血流感染。生物膜具有由微生物和周围细胞外基质组成的复杂结构。生物膜对抗真菌药物和宿主环境具有耐药性，因此难以治疗。近四分之一的败血症患者存在混合微生物感染。这些混合微生物生物膜，特别是包含真菌和细菌跨界物种的生物膜，可导致住院时间延长和高死亡率。本综述概述了双物种生物膜与白色念珠菌以及临床重要细菌金黄色葡萄球菌、铜绿假单胞菌和大肠杆菌的独特相互作用。
