Biswas Ujjwal Kumar, Bose Anindya
School of Pharmaceutical Science (SPS), Siksha O Anusandhan(SOA) University, K.8, Kalinga Nagar, Ghatkia, Bhubaneswar-751003, Odisha, India.
Pharm Nanotechnol. 2024 Aug 29. doi: 10.2174/0122117385325593240820044758.
Nano-Structured Lipid Carriers (NLCs) are improved Solid Lipid Nanoparticles (SLNs) that recover the permanency and capacity of drug payload. There are 3 different types of NLCs which have been anticipated. The aforementioned Lipid Nano Particles (LNPs) possess possible tenders in drug delivery systems, cosmeceuticals, clinical research and many others. Here, we highlight the structure, ingredients, different manufacturing techniques and analysis of NLCs which are rudiments in formulating a unique drug delivery system. These types of formulations are therapeutically advantageous like skin hydration, occlusion and improved bioavailability as well as skin targeting. In this article, we have also discussed the features, and novelty of NLCs, different advantages as promising assistance in topical drug delivery systems, shortcomings and utilisations of LNPs by concentrating on NLCs.
纳米结构脂质载体（NLCs）是改良的固体脂质纳米粒（SLNs），可恢复药物载量的持久性和容量。已预期有3种不同类型的NLCs。上述脂质纳米颗粒（LNPs）在药物递送系统、药妆品、临床研究等方面具有潜在优势。在此，我们重点介绍NLCs的结构、成分、不同的制造技术和分析，这些是构建独特药物递送系统的基础。这类制剂具有治疗优势，如皮肤保湿、封闭作用、提高生物利用度以及皮肤靶向性。在本文中，我们还通过聚焦NLCs讨论了NLCs的特性、新颖性、作为局部药物递送系统的有前景辅助手段的不同优势、LNPs的缺点和用途。
