Northern California Institute for Research and Education (NCIRE), San Francisco, California, USA.
VA Advanced Imaging Research Center, Department of Veterans Affairs Medical Center, San Francisco, California, USA.
Alzheimers Dement. 2024 Oct;20(10):7232-7247. doi: 10.1002/alz.14234. Epub 2024 Sep 1.
We evaluated preliminary feasibility of a digital, culturally-informed approach to recruit and screen participants for the Alzheimer's Disease Neuroimaging Initiative (ADNI4).
Participants were recruited using digital advertising and completed digital surveys (e.g., demographics, medical exclusion criteria, 12-item Everyday Cognition Scale [ECog-12]), Novoic Storyteller speech-based cognitive test). Completion rates and assessment performance were compared between underrepresented populations (URPs: individuals from ethnoculturally minoritized or low education backgrounds) and non-URPs.
Of 3099 participants who provided contact information, 654 enrolled in the cohort, and 595 completed at least one assessment. Two hundred forty-seven participants were from URPs. Of those enrolled, 465 met ADNI4 inclusion criteria and 237 evidenced possible cognitive impairment from ECog-12 or Storyteller performance. URPs had lower ECog and Storyteller completion rates. Scores varied by ethnocultural group and educational level.
Preliminary results demonstrate digital recruitment and screening assessment of an older diverse cohort, including those with possible cognitive impairment, are feasible. Improving engagement and achieving educational diversity are key challenges.
A total of 654 participants enrolled in a digital cohort to facilitate ADNI4 recruitment. Culturally-informed digital ads aided enrollment of underrepresented populations. From those enrolled, 42% were from underrepresented ethnocultural and educational groups. Digital screening tools indicate > 50% of participants likely cognitively impaired. Completion rates and assessment performance vary by ethnocultural group and education.
我们评估了一种数字化、文化知情的方法招募和筛选阿尔茨海默病神经影像学倡议（ADNI4）参与者的初步可行性。
参与者通过数字广告招募，并完成数字调查（例如，人口统计学、医学排除标准、12 项日常认知量表 [ECog-12]）、Novoic Storyteller 基于语音的认知测试）。在代表性不足的人群（URP：来自少数民族或教育程度较低的群体）和非 URP 人群之间比较了完成率和评估表现。
在提供联系信息的 3099 名参与者中，有 654 名参加了该队列，有 595 名完成了至少一项评估。247 名参与者来自 URP。在注册的参与者中，有 465 人符合 ADNI4 纳入标准，有 237 人根据 ECog-12 或 Storyteller 表现表现出可能的认知障碍。URP 的 ECog 和 Storyteller 完成率较低。分数因民族文化群体和教育水平而异。
初步结果表明，对年龄较大的多样化队列进行数字化招募和筛选评估是可行的，包括可能有认知障碍的人群。提高参与度和实现教育多样性是关键挑战。
共有 654 名参与者注册了一个数字队列，以促进 ADNI4 的招募。文化知情的数字广告有助于招募代表性不足的人群。在注册的参与者中，有 42%来自代表性不足的民族文化和教育群体。数字筛选工具表明，超过 50%的参与者可能有认知障碍。完成率和评估表现因民族文化群体和教育水平而异。
