Department of Gastrointestinal Surgery, The Tenth Affiliated Hospital, Southern Medical University (Dongguan People's Hospital), Dongguan, Guangdong 523059, P.R. China.
Oncol Rep. 2024 Nov;52(5). doi: 10.3892/or.2024.8801. Epub 2024 Sep 2.
Cancer is a disease that poses a serious threat to human health, the occurrence and development of which involves complex molecular mechanisms. Long non‑coding RNAs (lncRNAs) and RNA‑binding proteins (RBPs) are important regulatory molecules within cells, which have garnered extensive attention in cancer research in recent years. The binding of lncRNAs and RBPs plays a crucial role in the post‑transcriptional regulation of mRNA, affecting the synthesis of proteins related to cancer by regulating the stability of mRNA. This, in turn, regulates the malignant biological behaviors of tumor cells, such as proliferation and metastasis, and serves an important role in therapeutic resistance. The present study reviewed the role of lncRNA‑RBP interactions in the regulation of mRNA stability in various malignant tumors, with a focus on the molecular mechanisms underlying this regulatory interaction. The aim of the present review was to gain a deeper understanding of these molecular mechanisms to provide new strategies and insights for the precise treatment of cancer.
癌症是一种严重威胁人类健康的疾病，其发生和发展涉及复杂的分子机制。长链非编码 RNA（lncRNA）和 RNA 结合蛋白（RBP）是细胞内重要的调节分子，近年来在癌症研究中受到广泛关注。lncRNA 和 RBP 的结合在 mRNA 的转录后调节中起着关键作用，通过调节 mRNA 的稳定性来影响与癌症相关的蛋白质的合成，从而调节肿瘤细胞的恶性生物学行为，如增殖和转移，并在治疗抵抗中发挥重要作用。本研究综述了 lncRNA-RBP 相互作用在各种恶性肿瘤中调节 mRNA 稳定性的作用，重点介绍了这种调节相互作用的分子机制。本综述的目的是更深入地了解这些分子机制，为癌症的精确治疗提供新的策略和思路。
