Department of Otorhinolaryngology, University of Ilorin, Ilorin, Kwara State, Nigeria.
Department of Ear, Nose and Throat, University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria.
Niger Postgrad Med J. 2024 Jul 1;31(3):269-273. doi: 10.4103/npmj.npmj_10_24. Epub 2024 Sep 2.
The mucociliary clearance system is an important component in the prevention of chronic inflammation of the nasal and paranasal sinus.
The study aims to establish the normal values of mucociliary clearance in our region and to study the variation in mucociliary activity in patients with chronic rhinosinusitis in Ilorin, North-central Nigeria.
This was a prospective, cross-sectional study using consecutive consenting participants in both the control and study groups carried out at both family medicine and otorhinolaryngology clinics among patients attending the clinics.
After ethical approval was sought, informed consent was obtained from patients, a modified version of the validated health questionnaire was filled, semi-structured questionnaires were also filled after which patient undergo anterior rhinoscopy, nasal patency test and spirometry was done. The saccharine test has been used to measure nasal-mucociliary clearance time in the past.
All information were entered into SPSS version 20 and analysed descriptively, and results were presented in tables and figures.
Consecutive consenting 125 patients with rhinosinusitis (study group) and those without rhinosinusitis (control group) underwent naso-mucociliary clearance test. There were 34 males and 91 females with a male:female ratio of 1:2.6 among the study group and 55 males and 70 females with a male:female ratio of 1:1.3 for the control group. The age range was from 18 to 68 years with 18-40 years constituting the modal age group. The mean age for the studied group was 35.7 years while that of the control group was 33.1 years. The mean naso-mucociliary clearance time among the study group was 35.1 min standard deviation (SD = 12.32 ± 1.63), while among the control group, it was 14.8 min (SD = 5.59 ± 0.43).
Compared to the control group, there was a roughly 200% prolonged increase in the duration of naso-mucociliary clearance time among patients with rhinosinusitis. There was also a positive correlation with increasing age. Future studies comparing the pre-operative and post-operative treatment of rhinosinusitis will contribute to knowledge.
黏液纤毛清除系统是预防鼻和鼻旁窦慢性炎症的重要组成部分。
本研究旨在确定我们地区的黏液纤毛清除正常值，并研究尼日利亚中北部伊洛林慢性鼻-鼻窦炎患者的纤毛活动变化。
这是一项前瞻性、横断面研究，在家庭医学和耳鼻喉科诊所连续纳入对照组和研究组的同意参与者，在诊所就诊的患者中进行。
在获得伦理批准后，向患者征求知情同意，填写经过验证的健康问卷的修改版，填写半结构化问卷后，进行前鼻镜检查、鼻通气测试和肺活量测定。过去曾使用糖精试验来测量鼻黏膜清除时间。
所有信息均输入 SPSS 版本 20 进行描述性分析，并以表格和图形呈现结果。
连续同意的 125 例鼻窦炎患者（研究组）和无鼻窦炎患者（对照组）进行了鼻-黏膜清除试验。研究组中有 34 名男性和 91 名女性，男女比例为 1:2.6；对照组中，55 名男性和 70 名女性，男女比例为 1:1.3。年龄范围为 18 至 68 岁，18-40 岁构成模态年龄组。研究组的平均年龄为 35.7 岁，对照组的平均年龄为 33.1 岁。研究组的平均鼻黏膜清除时间为 35.1 分钟（标准差 [SD] = 12.32 ± 1.63），而对照组为 14.8 分钟（SD = 5.59 ± 0.43）。
与对照组相比，鼻窦炎患者的鼻黏膜清除时间延长了约 200%。年龄越大，相关性越强。未来比较鼻-鼻窦炎术前和术后治疗的研究将有助于知识的发展。
