Aryal Susmita, Park Sanghyo, Cho Hyeyoun, Choi Kang Chan, Choi Moon Jung, Park Yong Serk, Key Jaehong
Department of Biomedical Engineering, Yonsei University, Mirae Campus, Wonju, Korea.
Department of Biomedical Laboratory Science, Yonsei University, Mirae Campus, Wonju, Korea.
Biomed Eng Lett. 2024 Jun 12;14(5):1113-1124. doi: 10.1007/s13534-024-00396-x. eCollection 2024 Sep.
The purpose of this study was to investigate the potential of discoidal polymeric particles (DPPs) coated with macrophage membranes as a novel drug delivery system. The study aimed to determine whether these coated particles could reduce phagocytosis, and target specific organs, thereby enhancing drug delivery efficacy. In this study, discoidal polymeric particles (DPPs) were synthesized by a top-down fabrication method serving as the core drug delivery platform. The method involved the fusion of macrophage cell membrane vesicles with DPPs, resulting in macrophage membrane coated DPPs. This process aimed to translocate membrane proteins from macrophages onto the DPPs, rendering them structurally and functionally like host cells. The results of this study showed that macrophage membrane coated DPPs exhibited a threefold reduction in phagocytosis compared to bare DPPs. This reduction in phagocytosis indicated the potential of these coated DPPs to evade immune clearance. Time-lapse microscopy further illustrated the distinct interactions of macrophage membrane coated DPPs with immune cells. Biodistribution studies revealed that these coated particles displayed preferential accumulation in the lungs at early time points, followed by sustained accumulation in the liver. In conclusion, this study demonstrated that macrophage membrane coated DPPs represent a unique and promising strategy for drug delivery. These particles can mimic cell surfaces, reduce phagocytosis, and target specific organs. This opens exciting avenues for improving drug delivery efficacy in diverse therapeutic contexts. These findings advance our understanding of nanomedicine's potential in personalized therapies and targeted drug delivery strategies.
The online version contains supplementary material available at 10.1007/s13534-024-00396-x.
本研究的目的是研究包被巨噬细胞膜的盘状聚合物颗粒（DPPs）作为一种新型药物递送系统的潜力。该研究旨在确定这些包被颗粒是否可以减少吞噬作用，并靶向特定器官，从而提高药物递送效率。在本研究中，通过自上而下的制备方法合成了盘状聚合物颗粒（DPPs），作为核心药物递送平台。该方法包括将巨噬细胞膜囊泡与DPPs融合，从而得到包被巨噬细胞膜的DPPs。这一过程旨在将巨噬细胞的膜蛋白转移到DPPs上，使其在结构和功能上类似于宿主细胞。本研究结果表明，与未包被的DPPs相比，包被巨噬细胞膜的DPPs吞噬作用降低了三倍。吞噬作用的降低表明这些包被的DPPs具有逃避免疫清除的潜力。延时显微镜进一步说明了包被巨噬细胞膜的DPPs与免疫细胞之间独特的相互作用。生物分布研究表明，这些包被颗粒在早期优先在肺部积累，随后在肝脏中持续积累。总之，本研究表明，包被巨噬细胞膜的DPPs代表了一种独特且有前景的药物递送策略。这些颗粒可以模拟细胞表面，减少吞噬作用，并靶向特定器官。这为在不同治疗环境中提高药物递送效率开辟了令人兴奋的途径。这些发现推进了我们对纳米医学在个性化治疗和靶向药物递送策略中潜力的理解。
在线版本包含可在10.1007/s13534-024-00396-x获取的补充材料。
