Mueller R A, Towle A C, Breese G R
Regul Pept. 1985 Mar;10(2-3):157-66. doi: 10.1016/0167-0115(85)90010-2.
Rats treated neonatally with pargyline and 5,7-dihydroxytryptamine to decrease central serotonin-containing neurons have an accentuated respiratory response to i.c.v. thyrotropin-releasing hormone (TRH). Since these treated rats also evidence an elevated PaCO2, we sought to evaluate the importance of CO2 in determining the magnitude of the respiratory response to TRH. Neonatal treatment with capsaicin or acute vagotomy also produced adult animals whose basal PaCO2 was elevated and whose respiratory response to TRH was greater than that seen in control rats with lower PaCO2 values. In normal rats, however, administration of CO2 immediately before and after TRH administration does not alter the subsequent response to TRH. Thus, it appears that TRH facilitates the processing of CO2-dependent afferent impulses, and that CO2 does not alter disposition or pharmacokinetics of TRH.
新生期用优降宁和5,7-二羟基色胺处理以减少中枢含5-羟色胺能神经元的大鼠，对脑室内注射促甲状腺激素释放激素（TRH）的呼吸反应增强。由于这些处理过的大鼠也表现出动脉血二氧化碳分压（PaCO2）升高，我们试图评估二氧化碳在确定对TRH呼吸反应强度方面的重要性。用辣椒素进行新生期处理或急性迷走神经切断术也产生了成年动物，其基础PaCO2升高，并且其对TRH的呼吸反应大于PaCO2值较低的对照大鼠。然而，在正常大鼠中，在TRH给药前后立即给予二氧化碳不会改变随后对TRH的反应。因此，似乎TRH促进了二氧化碳依赖性传入冲动的处理，并且二氧化碳不会改变TRH的处置或药代动力学。
