McCown T J, Hedner J A, Towle A C, Breese G R, Mueller R A
Brain Res. 1986 May 14;373(1-2):189-96. doi: 10.1016/0006-8993(86)90330-6.
When rats received microinjections of 100 ng thyrotropin-releasing hormone (TRH) into the medial portions of the nucleus tractus solitarius and 12th nucleus or raphe obscurus, at the level of the obex, a significant decrease in the inspiratory time was found. Examination of TRH immunocytochemistry revealed a high density of TRH-positive nerve terminals in these regions, especially the more caudal aspects. If serotonin was depleted by neonatal 5,7-dihydroxytryptamine treatment, the respiratory response of the adults to TRH appeared potentiated. Even though the neonatal 5,7-dihydroxytryptamine reduces the occurrence of TRH-positive cell bodies, TRH-positive fibers were not appreciably altered. These results are discussed with regard to a possible role of endogenous TRH in the brainstem on rhythmic respiratory activity.
当在闩平面将100纳克促甲状腺激素释放激素（TRH）微量注射到孤束核内侧部分、第12核或中缝隐核时，发现吸气时间显著缩短。TRH免疫细胞化学检查显示，这些区域，尤其是更靠尾端的部分，有高密度的TRH阳性神经末梢。如果通过新生期5,7-二羟基色胺处理使血清素耗竭，成年动物对TRH的呼吸反应似乎增强。尽管新生期5,7-二羟基色胺会减少TRH阳性细胞体的出现，但TRH阳性纤维并未明显改变。就脑干中内源性TRH对节律性呼吸活动可能发挥的作用对这些结果进行了讨论。
