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意大利北部一家三级大学医院出现1例由埃可病毒11型引起的新生儿暴发性肝炎病例,涉及一对男性双胞胎:对一个可能的免疫学线索的深入了解。

A new case of Echovirus 11 neonatal fulminant hepatitis involving male twins in a Northern Italy Tertiary University Hospital: Insight on a possible immunological clue.

作者信息

Novazzi Federica, Piralla Antonio, Perniciaro Simona, Genoni Angelo Paolo, Ferrante Francesca Drago, Giardina Federica, Ferrari Guglielmo, Pellegrinelli Laura, Clementi Nicola, Pariani Elena, Zanoni Ivan, Baldanti Fausto, Agosti Massimo, Mancini Nicasio

机构信息

University of Insubria, Department of Medicine and Technological Innovation Varese, Varese, Italy.

ASST Sette Laghi, Laboratory of Medical Microbiology and Virology, Varese, Italy.

出版信息

IJID Reg. 2024 Jul 26;12:100411. doi: 10.1016/j.ijregi.2024.100411. eCollection 2024 Sep.

Abstract

The European Center for Disease Prevention and Control has reported 19 cases of severe echovirus 11 infections in neonates since 2022, nine of which were fatal. We report a new fatal neonatal case that occurred in a male twin for which we evaluated the respiratory and intestinal mucosal innate immune response.

摘要

自2022年以来,欧洲疾病预防控制中心报告了19例新生儿感染11型埃可病毒的严重病例,其中9例死亡。我们报告了一例新的致命新生儿病例,该病例发生在一名男性双胞胎身上,我们对其呼吸道和肠道黏膜的先天性免疫反应进行了评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a29/11363566/1d57a219515d/gr1a.jpg

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