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超乎寻常:对色素减退性蕈样肉芽肿的见解——一例报告

Beyond the pale: Insights into hypopigmented mycosis fungoides - A case report.

作者信息

Nur Zafirah Zauddin, Abdul Hadi Azwanis

机构信息

MBBS, Department of Family Medicine, Faculty of Medicine , International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Kuantan, Pahang, Malaysia. Email:

MBChB, M.Med (FamMed), Department of Family Medicine, Faculty of Medicine, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Kuantan, Pahang, Malaysia.

出版信息

Malays Fam Physician. 2024 Aug 17;19:47. doi: 10.51866/cr.644. eCollection 2024.

Abstract

Hypopigmented mycosis fungoides (MF) is a rare variant of cutaneous T-cell lymphoma, a type of extranodal non-Hodgkin lymphoma. This report presents the case of a 9-year-old boy with a 2-year history of asymptomatic, hypopigmented skin lesions that were resistant to topical treatment. He was initially treated for a fungal skin infection and had received multiple courses of topical antifungals and steroids but showed no improvement, which led to further evaluation and a referral to a dermatologist. A skin biopsy was performed, and the diagnosis of hypopigmented MF was confirmed through skin histopathology and immunohistochemistry study. His lesions responded well to cycles of narrowband ultraviolet B phototherapy, showing almost complete clearance after 4 months without any side effects.

摘要

色素减退性蕈样肉芽肿(MF)是皮肤T细胞淋巴瘤的一种罕见变异型,属于结外非霍奇金淋巴瘤的一种。本报告介绍了一名9岁男孩的病例,其有无症状色素减退性皮肤病变2年,对局部治疗耐药。他最初因皮肤真菌感染接受治疗,接受了多个疗程的局部抗真菌药和类固醇治疗,但未见改善,这促使进一步评估并转诊至皮肤科医生处。进行了皮肤活检,通过皮肤组织病理学和免疫组织化学研究确诊为色素减退性MF。他的皮损对窄谱中波紫外线光疗周期反应良好,4个月后几乎完全消退,且无任何副作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71db/11366274/efcbff387298/MFP-19-47-g1.jpg

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