Division of Dermatology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Clin Exp Dermatol. 2012 Mar;37(2):149-52. doi: 10.1111/j.1365-2230.2011.04197.x. Epub 2012 Jan 25.
Hypopigmented mycosis fungoides (MF) is a rare variant of cutaneous T-cell lymphoma. To date, there have been no data published about the efficacy of a twice-weekly regimen of narrowband ultraviolet B (NB-UVB) for the treatment of hypopigmented MF. We retrospectively reviewed 11 patients with hypopigmented MF who were treated with NB-UVB twice weekly between 2001 and 2010. Of the 11 patients, 7 achieved a complete response with a mean of 40 treatments; the remaining 4 patients had a partial response. Upon discontinuation of treatment, three patients had clinical relapse after complete remission. Median time to relapse was 10 months. A twice-weekly regimen of NB-UVB is an effective treatment for hypopigmented MF with minimal side-effects. However, the relapse rate is high, and unfortunately, no clinical or histological features can predict the relapse of the disease.
色素减退性蕈样肉芽肿（MF）是皮肤 T 细胞淋巴瘤的一种罕见变异型。迄今为止，尚无关于每周两次窄带紫外线 B（NB-UVB）治疗色素减退性 MF 的疗效的数据。我们回顾性分析了 2001 年至 2010 年间每周两次接受 NB-UVB 治疗的 11 例色素减退性 MF 患者。11 例患者中，7 例获得完全缓解，平均治疗 40 次；其余 4 例患者有部分缓解。停止治疗后，3 例完全缓解后出现临床复发。中位复发时间为 10 个月。每周两次的 NB-UVB 方案是一种治疗色素减退性 MF 的有效方法，副作用极小。然而，复发率很高，不幸的是，没有临床或组织学特征可以预测疾病的复发。
