白细胞线粒体DNA拷贝数与心血管疾病：队列研究的系统评价和荟萃分析
Leukocyte mitochondrial DNA copy number and cardiovascular disease: A systematic review and meta-analysis of cohort studies.
作者信息
Li Xinying, Liu Xiaoning, Chen Xiaojuan, Wang Yanqi, Wu Shuning, Li Fengjuan, Su Yuhao, Chen Lifang, Xiao Jian, Ma Jianping, Qin Pei
机构信息
Center for Clinical Epidemiology and Evidence-Based Medicine, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, Guangdong, China.
School of Public Health, Shantou University, Shantou, Guangdong, China.
出版信息
iScience. 2024 Jul 17;27(9):110522. doi: 10.1016/j.isci.2024.110522. eCollection 2024 Sep 20.
Increasing cohort studies have examined the link between mitochondrial DNA copy number (mtDNA-CN) and cardiovascular disease (CVD), with inconsistent findings. We searched PubMed, EMBASE, and Web of Science up to July 11, 2023 and used a random-effects model to calculate summary hazard ratios (HRs) and 95% confidence intervals (CIs). This systematic review and meta-analysis included 8 articles encompassing 29 studies with 646,398 participants. Individuals with the lowest mtDNA-CN had a summary HR of 1.27 (95% CI 1.02-1.59) for CVD, 1.18 (95% CI 0.92-1.50) for coronary heart disease (CHD), 1.10 (95% CI 0.89-1.37) for stroke, and 1.30 (95% CI 1.07-1.56) for heart failure (HF). Decreased mtDNA-CN is linked to an increased risk of CVD and HF but not CHD and stroke. These findings suggest mtDNA-CN from leukocytes may be a potential early biomarker for CVD. However, more prospective studies with long follow-up are needed.
越来越多的队列研究探讨了线粒体DNA拷贝数（mtDNA-CN）与心血管疾病（CVD）之间的联系，但结果并不一致。我们检索了截至2023年7月11日的PubMed、EMBASE和Web of Science数据库，并使用随机效应模型计算汇总风险比（HR）和95%置信区间（CI）。这项系统评价和荟萃分析纳入了8篇文章，涵盖29项研究，共646,398名参与者。mtDNA-CN最低的个体发生CVD的汇总HR为1.27（95%CI 1.02-1.59），冠心病（CHD）为1.18（95%CI 0.92-1.50），中风为1.10（95%CI 0.89-1.37），心力衰竭（HF）为1.30（95%CI 1.07-1.56）。mtDNA-CN降低与CVD和HF风险增加有关，但与CHD和中风无关。这些发现表明，白细胞中的mtDNA-CN可能是CVD的一种潜在早期生物标志物。然而，需要更多长期随访的前瞻性研究。
Zotero 插件