Zhou Bangyuan, Niu Yali, Wang Dan, Liu Liangpo, Guo Jianquan
School of Public Health, Shanxi Medical University, 56 Xinjiannan Road, Taiyuan, 030001 Shanxi People's Republic of China.
Key Laboratory of Coal Environmental Pathogenicity and Prevention, (Shanxi Medical University), Ministry of Education, Taiyuan, People's Republic of China.
Food Sci Biotechnol. 2024 Apr 17;33(13):3119-3130. doi: 10.1007/s10068-024-01564-6. eCollection 2024 Oct.
Bisphenol A has become a global public health problem. As an antioxidant, geraniol has potential preventive effects against toxicity. This study analyzes the preventive effect of geraniol against BPA induced liver injury in CD-1 mice. Geraniol administration significantly ameliorated BPA induced liver damage by the increase in superoxide dismutase/catalase enzymatic activities, and decrease in malonaldehyde level; prompted a significant reduction in the expression levels of inflammatory cytokines (, , and ), and pyroptosis biomarkers (, , and ); up-regulated the expression of , , and markedly, which exhibited intestinal barrier function. Also, geraniol treatment optimized the composition and diversity of gut microbiota. It may be summarized that geraniol showed protective effects on liver injury induced by BPA and further revealed that the mechanism might be located on improving intestinal physical barrier function, down-regulating pyroptosis biomarkers, and normalizing intestinal microbiota, consequently reducing inflammatory response in the liver.
双酚A已成为一个全球性的公共卫生问题。香叶醇作为一种抗氧化剂，对毒性具有潜在的预防作用。本研究分析了香叶醇对CD-1小鼠中双酚A诱导的肝损伤的预防作用。给予香叶醇可通过超氧化物歧化酶/过氧化氢酶活性增加以及丙二醛水平降低，显著改善双酚A诱导的肝损伤；促使炎症细胞因子（、和）以及细胞焦亡生物标志物（、和）的表达水平显著降低；明显上调、和的表达，这些基因表现出肠道屏障功能。此外，香叶醇治疗优化了肠道微生物群的组成和多样性。可以总结为，香叶醇对双酚A诱导的肝损伤具有保护作用，并进一步揭示其机制可能在于改善肠道物理屏障功能、下调细胞焦亡生物标志物以及使肠道微生物群正常化，从而减轻肝脏中的炎症反应。
