Department of Animal Science & Technology and BET Research Institute, Chung-Ang University, Anseong, Gyeonggi-do 17546, Korea.
Biomolecules. 2020 Jul 25;10(8):1105. doi: 10.3390/biom10081105.
Bisphenol A (BPA) is an oestrogenic endocrine disruptor widely used in the production of certain plastics, e.g., polycarbonate, hard and clear plastics, and epoxy resins that act as protective coating for food and beverage cans. Human exposure to this chemical is thought to be ubiquitous. BPA alters endocrine function, thereby causing many diseases in human and animals. In the last few decades, studies exploring the mechanism of BPA activity revealed a direct link between BPA-induced oxidative stress and disease pathogenesis. Antioxidants, reducing agents that prevent cellular oxidation reactions, can protect BPA toxicity. Although the important role of antioxidants in minimizing BPA stress has been demonstrated in many studies, a clear consensus on the associated mechanisms is needed, as well as the directives on their efficacy and safety. Herein, considering the distinct biochemical properties of BPA and antioxidants, we provide a framework for understanding how antioxidants alleviate BPA-associated stress. We summarize the current knowledge on the biological function of enzymatic and non-enzymatic antioxidants, and discuss their practical potential as BPA-detoxifying agents.
双酚 A（BPA）是一种雌激素内分泌干扰物，广泛用于某些塑料的生产，例如聚碳酸酯、硬而透明的塑料和环氧树脂，它们用作食品和饮料罐的保护涂层。人们认为这种化学物质无处不在。BPA 会改变内分泌功能，从而导致人类和动物的许多疾病。在过去的几十年中，研究 BPA 活性的机制揭示了 BPA 诱导的氧化应激与疾病发病机制之间的直接联系。抗氧化剂是一种防止细胞氧化反应的还原剂，可以保护 BPA 毒性。尽管许多研究已经证明了抗氧化剂在最小化 BPA 应激方面的重要作用，但需要就相关机制达成明确共识，并就其功效和安全性做出指示。在此，考虑到 BPA 和抗氧化剂的不同生化特性，我们提供了一个理解抗氧化剂如何缓解 BPA 相关应激的框架。我们总结了关于酶和非酶抗氧化剂的生物学功能的现有知识，并讨论了它们作为 BPA 解毒剂的实际潜力。
