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定制八钙磷酸酯的超快且可重现合成

Ultrafast and Reproducible Synthesis of Tailor-Made Octacalcium Phosphate.

作者信息

Choudhary Rajan, Indurkar Abhishek, Rubenis Kristaps, Grava Andra, Dubnika Arita, Hurle Katrin, Locs Janis

机构信息

School of Chemistry, University College Dublin, Belfield Dublin 4, Ireland.

Institute of Biomaterials and Bioengineering, Faculty of Natural Sciences and Technology, Riga Technical University, Pulka St 3, Riga LV-1007, Latvia.

出版信息

ACS Omega. 2024 Aug 14;9(34):36165-36176. doi: 10.1021/acsomega.4c01436. eCollection 2024 Aug 27.

DOI:10.1021/acsomega.4c01436
PMID:39220503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11360017/
Abstract

Octacalcium phosphate (OCP) has excellent bone formation ability and a good resorption rate as compared to the commercial bone substitutes [, Bio-Oss (Geistlich Pharma AG) and MBCP+ (Biomatlante)], as well as synthesized biomaterials (hydroxyapatite and tricalcium phosphate). The synthesis approach to obtain phase-pure OCP possesses a great challenge due to its complex reaction mechanism and narrow synthesis window. Thus, the current study aimed to overcome the synthesis challenges and to define the precise reaction conditions required for controllable and reproducible synthesis of OCP. Using the principles of the coprecipitation method, novel synthesis protocols were developed ensuring ultrafast synthesis of OCP within minutes. XRD analysis confirmed that phase-pure OCP was obtained. These processing schemes enabled the synthesis of tailor-made OCP with specific surface areas ranging from 16 to 91 m/g. The synthesized OCPs exhibited plate-like morphology. The interaction of the synthesized OCPs with MC3T3-E1 cells was found to be nontoxic, confirming their cytocompatibility. The synthesis approach developed in this study indicates that challenges such as the reaction volume, stirring rate, and flow rate need to be addressed in the future to upscale the technology.

摘要

与市售骨替代物[Bio-Oss（盖氏制药公司）和MBCP+（Biomatlante）]以及合成生物材料（羟基磷灰石和磷酸三钙）相比，八钙磷酸酯（OCP）具有出色的骨形成能力和良好的吸收率。由于其复杂的反应机制和狭窄的合成窗口，获得纯相OCP的合成方法面临巨大挑战。因此，当前的研究旨在克服合成挑战，并确定可控且可重复合成OCP所需的精确反应条件。利用共沉淀法的原理，开发了新颖的合成方案，确保在几分钟内超快合成OCP。X射线衍射分析证实获得了纯相OCP。这些工艺方案能够合成比表面积范围为16至91平方米/克的定制OCP。合成的OCP呈现出板状形态。发现合成的OCP与MC3T3-E1细胞的相互作用无毒，证实了它们的细胞相容性。本研究中开发的合成方法表明，未来需要解决诸如反应体积、搅拌速率和流速等挑战，以扩大该技术的规模。

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