van Schouwenburg J A
S Afr Med J. 1985 May 11;67(19):754-8.
In this study the parameters of normal ovarian cycles were prospectively applied in a programme of ovulation induction with human menopausal gonadotrophin (HMG) and human chorionic gonadotrophin (HCG). Hypo-oestrogenism and failure of clomiphene administration were the main indications for treating 42 patients during 128 cycles with gonadotrophins. The initial HMG dosage was 1 ampoule per day. The dosage was adjusted daily in accordance with serum oestradiol response and ultrasound findings. HCG was administered under the following conditions: average follicle size of at least 18 mm, not more than 2 follicles present, optimal cervical mucus, and serum oestradiol levels between 1 000 and 3 000 pmol/l. Ovulation was successfully induced in 90% of treated cycles and 20 pregnancies ensued. If anovulatory patients with additional causes for infertility were excluded, the pregnancy rate per treated cycle was 30%. Two twin pregnancies developed and no cases of clinical ovarian hyperstimulation syndrome occurred. The maximum follicle size and cervical mucus score did not differ significantly from these parameters in spontaneous ovulatory cycles. Preovulatory serum oestradiol levels and mid-luteal progesterone levels, however, were significantly higher in the gonadotrophin-stimulated cycles.
在本研究中，正常卵巢周期的参数被前瞻性地应用于用人绝经期促性腺激素（HMG）和人绒毛膜促性腺激素（HCG）进行的排卵诱导方案。低雌激素血症和克罗米芬治疗失败是在128个周期中对42例患者用促性腺激素治疗的主要指征。初始HMG剂量为每天1支。剂量根据血清雌二醇反应和超声检查结果每日调整。在以下条件下给予HCG：平均卵泡大小至少18mm，存在的卵泡不超过2个，宫颈黏液最佳，血清雌二醇水平在1000至3000pmol/l之间。90%的治疗周期成功诱导排卵，随后有20例妊娠。如果排除伴有其他不孕原因的无排卵患者，则每个治疗周期的妊娠率为30%。发生了2例双胎妊娠，未出现临床卵巢过度刺激综合征病例。最大卵泡大小和宫颈黏液评分与自然排卵周期中的这些参数相比无显著差异。然而，促性腺激素刺激周期中的排卵前血清雌二醇水平和黄体中期孕酮水平显著更高。
