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病例报告：一名成人枕部罕见的具有上皮样形态的恶性孤立性纤维性肿瘤。

Case report: A rare case of malignant solitary fibrous tumor in an adult with an epithelioid pattern in the occipital region.

作者信息

Huang Ke, Liu Wen-Wen, Chen Xiu-Wen, Hao Yin-Hua, Luo Sen-Yuan, Yuan Ling-Ling, Huang Yu-Gang, Tang Xian-Bin

机构信息

Department of Pathology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.

出版信息

Front Oncol. 2024 Aug 16;14:1339582. doi: 10.3389/fonc.2024.1339582. eCollection 2024.

DOI:10.3389/fonc.2024.1339582
PMID:39220647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11361973/
Abstract

We illustrated a rare case of malignant solitary fibrous tumor (MSFT) with epithelioid morphology in the occipital region of a 59-year-old female, in which a rare NAB2ex7-STAT6 exon15/16 double fusion subtype was detected by the Next-generation sequencing (NGS) and STAT6 immunohistochemistry (IHC) was diffusely and strongly positively expressed, without recurrence after 20 months of postoperative follow-up. The morphological and molecular genetic aspects and the differential diagnosis are described, and the relevant literature was assessed in order to broaden our understanding and diagnostic capability of this malignancy.

摘要

我们阐述了一例发生于一名59岁女性枕部区域、具有上皮样形态的罕见恶性孤立性纤维瘤（MSFT）病例，通过二代测序（NGS）检测到一种罕见的NAB2ex7-STAT6 exon15/16双融合亚型，且STAT6免疫组化（IHC）弥漫性强阳性表达，术后随访20个月无复发。描述了其形态学和分子遗传学特征及鉴别诊断，并评估了相关文献，以拓宽我们对这种恶性肿瘤的认识和诊断能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e2/11361973/77f594e1e115/fonc-14-1339582-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e2/11361973/efb032b90b34/fonc-14-1339582-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e2/11361973/77f594e1e115/fonc-14-1339582-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e2/11361973/efb032b90b34/fonc-14-1339582-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e2/11361973/77f594e1e115/fonc-14-1339582-g002.jpg

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Br J Surg. 2023 Nov 9;110(12):1850-1856. doi: 10.1093/bjs/znad290.
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[Malignant solitary fibrous tumor with osteosarcoma components: a clinocopathological analysis of two cases].[伴有骨肉瘤成分的恶性孤立性纤维性肿瘤：2例临床病理分析]
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Relapsed Synovial Sarcoma: Treatment Options.复发性滑膜肉瘤：治疗选择。
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Clear cell sarcoma: state-of-the art and perspectives.透明细胞肉瘤：现状与展望。
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Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell sarcoma: focus on immunohistochemical profile and association with Epstein-Barr virus.炎症性假瘤样滤泡性/纤维母细胞性树突状细胞肉瘤：聚焦免疫组化特征及与爱泼斯坦-巴尔病毒的关联
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Clear Cell Sarcoma of the Kidney (CCSK) With Fusion: A Rare Case Report With a Brief Review of the Literature.伴有融合的肾透明细胞肉瘤（CCSK）：1例罕见病例报告并文献简要回顾
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