Guo Haoyu, Guo Mingke, Xia Zhidao, Shao Zengwu
Department of Orthopaedic, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China.
Department of Orthopaedic, Beijing Jishuitan Hospital, Fourth Medical College of Peking University, Beijing, China.
Biomater Transl. 2024 Mar 28;5(1):33-45. doi: 10.12336/biomatertransl.2024.01.004. eCollection 2024.
Drug therapy towards tumours often causes adverse effects because of their non-specific nature. Membrane-coated technology and membrane-coated nanoparticles provide an advanced and promising platform of targeted and safe delivery. By camouflaging the nanoparticles with natural derived or artificially modified cell membranes, the nano-payloads are bestowed with properties from cell membranes such as longer circulation, tumour or inflammation-targeting, immune stimulation, augmenting the performance of traditional therapeutics. In this review, we review the development of membrane coating technology, and summarise the technical details, physicochemical properties, and research status of membrane-coated nanoparticles from different sources in tumour treatment. Finally, we also look forward to the prospects and challenges of transforming membrane coating technology from experiment into clinical use. Taken together, membrane-coated nanoparticles are bound to become one of the most potential anti-tumour strategies in the future.
针对肿瘤的药物治疗往往因其非特异性而产生不良反应。膜包被技术和膜包被纳米颗粒提供了一个先进且有前景的靶向和安全递送平台。通过用天然来源或人工修饰的细胞膜伪装纳米颗粒，纳米药物负载赋予了细胞膜的特性，如更长的循环时间、肿瘤或炎症靶向性、免疫刺激，增强了传统疗法的性能。在本综述中，我们回顾了膜包被技术的发展，并总结了不同来源的膜包被纳米颗粒在肿瘤治疗中的技术细节、理化性质和研究现状。最后，我们还展望了将膜包被技术从实验转化为临床应用的前景和挑战。综上所述，膜包被纳米颗粒必将成为未来最具潜力的抗肿瘤策略之一。
