Simpson W G, Tseng M T, Harty J I
Urol Res. 1985;13(1):23-6. doi: 10.1007/BF00571752.
The influence of the calcium blocker verapamil (VR) on systemic toxicity resulting from the intravesical instillation of Adriamycin (ADM) and thiotepa (THT) was assessed in mice. Eighty per cent of the animals receiving THT + VR developed a generalized alopecia. Data gathered at necroscopy failed to reveal any trauma to the major organs or the presence of a drug-induced myelosuppression. Combination of ADM and VR did not produce an enhancement of systemic toxicity, manifest as myelosuppression. The drug combination did not produce a cardiomyopathy as assessed by histologic examination. The use of VR in combination with antineoplastic agents posed no more of a threat to the animals than did the use of cytotoxin alone.
在小鼠中评估了钙通道阻滞剂维拉帕米（VR）对膀胱内灌注阿霉素（ADM）和噻替派（THT）所致全身毒性的影响。接受THT + VR的动物中有80%出现了全身性脱发。尸检收集的数据未能发现主要器官有任何损伤或药物诱导的骨髓抑制现象。ADM与VR联合使用并未增强表现为骨髓抑制的全身毒性。经组织学检查评估，该药物组合未导致心肌病。与单独使用细胞毒素相比，VR与抗肿瘤药物联合使用对动物造成的威胁并未增加。
