Department of Medicine, Section of Gastroenterology, Aga Khan University Hospital, Sindh, Karachi 74800, Pakistan.
World J Gastroenterol. 2024 Aug 28;30(32):3743-3747. doi: 10.3748/wjg.v30.i32.3743.
Liver cirrhosis has long been considered a point of no return, with limited hope for recovery. However, recent advancements, particularly the Baveno VII criteria and the utilization of transjugular intrahepatic portosystemic shunt (TIPS), have illuminated the concept of hepatic recompensation. In this editorial we comment on the article by Gao published in the recent issue. This editorial provides a comprehensive overview of the evolution of understanding cirrhosis, the criteria for recompensation, and the efficacy of TIPS in achieving recompensation. We discuss key findings from recent studies, including the promising outcomes observed in patients who achieved recompensation post-TIPS insertion. While further research is needed to validate these findings and elucidate the mech-anisms underlying recompensation, the insights presented here offer renewed hope for patients with decompensated cirrhosis and highlight the potential of TIPS as a therapeutic option in their management.
肝硬化长期以来被认为是不可逆转的,恢复的希望有限。然而,最近的进展,特别是 Baveno VII 标准和经颈静脉肝内门体分流术(TIPS)的应用,阐明了肝代偿的概念。在这篇社论中,我们对 Gao 发表在最近一期的文章进行了评论。这篇社论全面概述了对肝硬化的理解、代偿标准以及 TIPS 实现代偿的疗效的演变。我们讨论了最近研究中的关键发现,包括 TIPS 后实现代偿的患者观察到的有希望的结果。虽然需要进一步的研究来验证这些发现并阐明代偿的机制,但这里提出的观点为失代偿性肝硬化患者带来了新的希望,并强调了 TIPS 在其管理中的治疗选择的潜力。