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聚合物心脏瓣膜的最新进展：从基础研究到临床试验。

Recent advancements in polymeric heart valves: From basic research to clinical trials.

作者信息

Wang Yuanchi, Fu Yulong, Wang Qingyu, Kong Deling, Wang Zhihong, Liu Jing

机构信息

Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China.

Key Laboratory of Bioactive Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, College of Life Science, Nankai University, Tianjin 300071, China.

出版信息

Mater Today Bio. 2024 Aug 10;28:101194. doi: 10.1016/j.mtbio.2024.101194. eCollection 2024 Oct.

DOI:10.1016/j.mtbio.2024.101194
PMID:39221196
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11364905/
Abstract

Valvular heart diseases (VHDs) have become one of the most prevalent heart diseases worldwide, and prosthetic valve replacement is one of the effective treatments. With the fast development of minimal invasive technology, transcatheter valves replacement has been exploring in recent years, such as transcatheter aortic valve replacement (TAVR) technology. In addition, basic research on prosthetic valves has begun to shift from traditional mechanical valves and biological valves to the development of polymeric heart valves. The polymeric heart valves (PHVs) have shown a bright future due to their advantages of longer durability, better biocompatibility and reduced cost. This review gives a brief history of the development of polymeric heart valves, provides a summary of the types of polymer materials suitable for heart leaflets and the emerging processing/preparation methods for polymeric heart valves in the basic research. Besides, we facilitate a deeper understanding of polymeric heart valve products that are currently in preclinical/clinical studies, also summary the limitations of the present researches as well as the future development trends. Hence, this review will provide a holistic understanding for researchers working in the field of prosthetic valves, and will offer ideas for the design and research of valves with better durability and biocompatibility.

摘要

心脏瓣膜病（VHDs）已成为全球最普遍的心脏病之一，人工瓣膜置换是有效的治疗方法之一。随着微创技术的快速发展，近年来一直在探索经导管瓣膜置换术，如经导管主动脉瓣置换术（TAVR）技术。此外，人工瓣膜的基础研究已开始从传统的机械瓣膜和生物瓣膜转向聚合物心脏瓣膜的开发。聚合物心脏瓣膜（PHVs）因其更长的耐用性、更好的生物相容性和更低的成本等优点而展现出光明的前景。本文综述了聚合物心脏瓣膜的发展简史，总结了适用于心脏瓣膜小叶的聚合物材料类型以及基础研究中聚合物心脏瓣膜新出现的加工/制备方法。此外，我们促进对目前处于临床前/临床研究阶段的聚合物心脏瓣膜产品有更深入的了解，还总结了当前研究的局限性以及未来的发展趋势。因此，本综述将为从事人工瓣膜领域研究的人员提供全面的理解，并为设计和研究具有更好耐用性和生物相容性的瓣膜提供思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4794/11364905/ce296d1f212d/gr14.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4794/11364905/ce296d1f212d/gr14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4794/11364905/3c1eddd6a145/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4794/11364905/65ef5b6e9348/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4794/11364905/7c5ba601975a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4794/11364905/d3dae90d6110/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4794/11364905/0058d459d015/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4794/11364905/6c6c56a97bae/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4794/11364905/a22c5e0c00f1/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4794/11364905/e14c73b43d9d/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4794/11364905/8086b8805e18/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4794/11364905/b5a94b75b271/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4794/11364905/5804e21a67fc/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4794/11364905/e697d5119c6d/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4794/11364905/6da8126b4154/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4794/11364905/c841425698fe/gr13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4794/11364905/ce296d1f212d/gr14.jpg

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