Zhang Yi, Yu Jinsheng, Pei Hang, Zhao Xinzheng, Wang Chao, Wang Guanyin, Shen Zan, Hua Jiang, He Bangjian
Zhejiang Chinese Medical University, Hangzhou, China.
Anji County Hospital of Traditional Chinese Medicine, Anji, China.
Front Genet. 2024 Feb 22;15:1263916. doi: 10.3389/fgene.2024.1263916. eCollection 2024.
Observational studies suggest a potential association between atmospheric particulate matter 2.5 (PM2.5) and osteoporosis, but a causal association is unclear due to the presence of confounding factors. We utilized bone mineral density indices at four specific sites to represent osteoporosis: femoral neck (FN-BMD), lumbar spine (LS-BMD), forearm (FA-BMD), and heel (HE-BMD). The PM2.5 data was obtained from the UK Biobank database, while the datasets for FN-BMD, LS-BMD, and FA-BMD were obtained from the GEFOS database, and the dataset for HE-BMD was obtained from the EBI database. A two-sample Mendelian randomization analysis was conducted using mainly the inverse variance weighted method, horizontal pleiotropy and heterogeneity were also assessed. The results indicated that PM2.5 was not correlated with a decrease in FN-BMD (β: -0.305, 95%CI: -0.762, 0.153), LS-BMD (β: 0.134, 95%CI: -0.396, 0.666), FA-BMD (β: -0.056, 95%CI: -1.172,1.060), and HE-BMD (β: -0.084, 95%CI: -0.261,0.093). Additionally, acceptable levels of horizontal pleiotropy and heterogeneity were observed. In contrast to most observational studies, our research did not discover a potential causal relationship between PM2.5 and the development of osteoporosis.
观察性研究表明，大气细颗粒物2.5（PM2.5）与骨质疏松症之间可能存在关联，但由于存在混杂因素，因果关系尚不清楚。我们使用四个特定部位的骨密度指标来代表骨质疏松症：股骨颈（FN-BMD）、腰椎（LS-BMD）、前臂（FA-BMD）和足跟（HE-BMD）。PM2.5数据来自英国生物银行数据库，而FN-BMD、LS-BMD和FA-BMD的数据集来自GEFOS数据库，HE-BMD的数据集来自EBI数据库。主要使用逆方差加权法进行两样本孟德尔随机化分析，同时评估水平多效性和异质性。结果表明，PM2.5与FN-BMD降低（β：-0.305，95%CI：-0.762，0.153）、LS-BMD降低（β：0.134，95%CI：-0.396，0.666）、FA-BMD降低（β：-0.056，95%CI：-1.172，1.060）和HE-BMD降低（β：-0.084，95%CI：-0.261，0.093）均无相关性。此外，观察到水平多效性和异质性处于可接受水平。与大多数观察性研究不同，我们的研究未发现PM2.5与骨质疏松症发生之间存在潜在因果关系。
