School of Physical Education, Shanghai University of Sport, Shanghai, China.
Shanghai I&C Foreign Languages School, Shanghai, China.
PeerJ. 2024 Aug 28;12:e17986. doi: 10.7717/peerj.17986. eCollection 2024.
This article aims to systematically evaluate the intervention effect of exercise on working memory in patients with depression.
Six Chinese and English databases were searched for randomized controlled trials (RCTs) about exercise on working memory in patients with depression. PEDro scale was adopted to evaluate the methodological quality of the included articles, GRADEpro scale was employed to evaluate the level of evidence for outcomes, and the Metafor Package in R 4.4.1 was used to analyze the combined effect size, subgroup analyses and publication bias.
A total of 15 studies were included. The meta-analysis indicated that exercise had a statistically significant effect on working memory in patients with depression, with an effect size of 0.16 (95% CI [0.03-0.28], = 0.02). Exercise type (F(3,34) = 1.99, = 0.13), intervention content (F(1,36) = 1.60, = 0.22), and exercise duration (F(1,36) = 0.05, = 0.83) did not moderate the effect, whereas exercise intensity showed a moderating effect (F(2,35) = 8.83, < 0.01). There was evidence of publication bias in the study results (t = 2.52, = 0.02).
Exercise can improve the working memory of patients with depression, and its moderating effect is the best when having low-intensity and moderate-intensity. Research plan was registered in international system evaluation platform PROSPERO (https://www.crd.york.ac.uk/PROSPERO/) (CRD42023475325).
本文旨在系统评价运动对抑郁症患者工作记忆的干预效果。
检索中文和英文数据库，纳入关于运动对抑郁症患者工作记忆影响的随机对照试验（RCT）。采用 PEDro 量表评价纳入文献的方法学质量，采用 GRADEpro 量表评价结局的证据等级，采用 R 4.4.1 版 Metafor 软件包分析合并效应量、亚组分析和发表偏倚。
共纳入 15 项研究。Meta 分析结果显示，运动对抑郁症患者的工作记忆有统计学意义的改善作用，效应量为 0.16（95%CI [0.03-0.28]， = 0.02）。运动类型（F（3，34）= 1.99， = 0.13）、干预内容（F（1，36）= 1.60， = 0.22）和运动持续时间（F（1，36）= 0.05， = 0.83）对效应无调节作用，而运动强度显示出调节作用（F（2，35）= 8.83， < 0.01）。研究结果存在发表偏倚（t = 2.52， = 0.02）。
运动可改善抑郁症患者的工作记忆，低强度和中强度运动的调节作用最佳。研究方案已在国际系统评价平台 PROSPERO（https://www.crd.york.ac.uk/PROSPERO/）注册（CRD42023475325）。
