de Medeiros Quirino Leonardo, da Silva Mendonça Tania Maria, Martins da Silva Carlos Henrique, Borges Martins da Silva Paro Helena
Medicine, Federal University of Uberlandia, Uberlandia, BRA.
Cureus. 2024 Aug 2;16(8):e66023. doi: 10.7759/cureus.66023. eCollection 2024 Aug.
Androgenetic alopecia (AGA) is the most common cause of hair loss in men and women, and it can affect the psychological and social activities of individuals, thus reducing their quality of life. Photobiomodulation (PBM) is a recent adjuvant treatment for this condition with promising results for hair regrowth. We aimed to assess the health-related quality of life of men and women with AGA before and after PBM sessions.
This is a single-center prospective observational study conducted with 42 men and 43 women with AGA. All participants answered a sociodemographic questionnaire in an interview and individually answered the Brazilian version of Skindex-29 (self-application). After 24 PBM sessions, two 20-minute sessions per week, with 48 to 72 hours of interval between sessions, participants answered the Skindex-29 again.
Women had a large reduction in Skindex-29 total score after PBM (p<0.01; d=0.82) and lower scores in the emotions (p<0.01; d=0.89), psychosocial functioning (p<0.01; d=0.60), and symptoms domains (p=0.03; d=0.38). Men presented a moderate reduction in Skindex-29 total score after PBM (p<0.01; d=0.68), largely lower scores in the emotions domain (p<0.01; d=0.82) and a small reduction in the psychosocial functioning domain (p<0.01; d=0.47).
The use of PBM in AGA is associated with improving the quality of life of men and women. This enhancement was higher regarding emotions, the major domain affected in the AGA population. Women had larger impacts on all domains of Skindex-29 after the use of PBM.
雄激素性脱发（AGA）是男性和女性脱发的最常见原因，它会影响个体的心理和社交活动，从而降低其生活质量。光生物调节（PBM）是最近针对这种情况的一种辅助治疗方法，对毛发生长有很有前景的效果。我们旨在评估接受PBM治疗前后AGA男性和女性与健康相关的生活质量。
这是一项单中心前瞻性观察性研究，对42名AGA男性和43名AGA女性进行。所有参与者在访谈中回答了一份社会人口学问卷，并单独回答了巴西版的Skindex-29（自行填写）。在每周进行两次、每次20分钟、每次间隔48至72小时的24次PBM治疗后，参与者再次回答Skindex-29。
女性在接受PBM治疗后Skindex-29总分大幅降低（p<0.01；d=0.82），在情绪（p<0.01；d=0.89）、心理社会功能（p<0.01；d=0.60）和症状领域（p=0.03；d=0.38）得分更低。男性在接受PBM治疗后Skindex-29总分适度降低（p<0.01；d=0.68），在情绪领域得分大幅降低（p<0.01；d=0.82），在心理社会功能领域得分小幅降低（p<0.01；d=0.47）。
在AGA中使用PBM与改善男性和女性的生活质量相关。这种改善在情绪方面更高，情绪是AGA人群中受影响的主要领域。女性在使用PBM后对Skindex-29的所有领域都有更大的影响。
