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先进放射治疗技术中金刚石剂量计的综述。

A review of diamond dosimeters in advanced radiotherapy techniques.

作者信息

Angelou Christina, Patallo Ileana Silvestre, Doherty Daniel, Romano Francesco, Schettino Giuseppe

机构信息

Department of Physics, University of Surrey, Guildford, UK.

Radiotherapy and Radiation Dosimetry, National Physical Laboratory (NPL), Teddington, UK.

出版信息

Med Phys. 2024 Dec;51(12):9230-9249. doi: 10.1002/mp.17370. Epub 2024 Sep 2.

Abstract

This review article synthesizes key findings from studies on the use of diamond dosimeters in advanced radiotherapy techniques, showcasing their applications, challenges, and contributions to enhancing dosimetric accuracy. The article explores various dosimeters, highlighting synthetic diamond dosimeters as potential candidates especially due to their high spatial resolution and negligible ion recombination effect. The clinically validated commercial dosimeter, PTW microDiamond (mD), faces limitations in small fields, proton and hadron therapy and ultra-high dose per pulse (UHDPP) conditions. Variability in reported values for field sizes 2 2 is noted, reflecting the competition between volume averaging and density perturbation effects. PTW's introduction of flashDiamond (fD) holds promise for dosimetric measurements in UHDPP conditions and is reliable for commissioning ultra-high dose rate (UHDR) electron beam systems, pending the clinical validation of the device. Other advancements in diamond detectors, such as in 3D configurations and real-time dose per pulse x-ray detectors, are considered valuable in overcoming challenges posed by modern radiotherapy techniques, alongside relative dosimetry and pre-treatment verifications. The studies discussed collectively provide a comprehensive overview of the evolving landscape of diamond dosimetry in the field of radiotherapy, and offer insights into future directions for research and development in the field.

摘要

这篇综述文章综合了关于在先进放疗技术中使用金刚石剂量计的研究的关键发现,展示了它们的应用、挑战以及对提高剂量测定准确性的贡献。文章探讨了各种剂量计,特别强调合成金刚石剂量计是潜在的候选者,这尤其是因为它们具有高空间分辨率和可忽略不计的离子复合效应。经过临床验证的商业剂量计PTW微金刚石(mD)在小射野、质子和强子治疗以及每脉冲超高剂量(UHDPP)条件下存在局限性。注意到对于2×2射野尺寸报告值的变异性,这反映了体积平均和密度微扰效应之间的竞争。PTW推出的闪速金刚石(fD)在UHDPP条件下进行剂量测定测量方面有前景,并且对于调试超高剂量率(UHDR)电子束系统是可靠的,不过该设备尚待临床验证。金刚石探测器的其他进展,例如三维配置和每脉冲实时剂量X射线探测器,在克服现代放疗技术带来的挑战以及相对剂量测定和治疗前验证方面被认为是有价值的。所讨论的这些研究共同提供了放疗领域中金刚石剂量测定不断演变的全面概述,并为该领域的未来研发方向提供了见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21ac/11656300/b1ae304a682d/MP-51-9230-g003.jpg

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