Papaconstadopoulos P, Tessier F, Seuntjens J
McGill University, Medical Physics Unit, Montreal General Hospital, Quebec, Canada.
Phys Med Biol. 2014 Oct 7;59(19):5937-52. doi: 10.1088/0031-9155/59/19/5937. Epub 2014 Sep 11.
The purpose of this study was to derive a complete set of correction and perturbation factors for output factors (OF) and dose profiles. Modern small field detectors were investigated including a plastic scintillator (Exradin W1, SI), a liquid ionization chamber (microLion 31018, PTW), an unshielded diode (Exradin D1V, SI) and a synthetic diamond (microDiamond 60019, PTW). A Monte Carlo (MC) beam model was commissioned for use in small fields following two commissioning procedures: (1) using intermediate and moderately small fields (down to 2 × 2 cm(2)) and (2) using only small fields (0.5 × 0.5 cm(2) -2 × 2 cm(2)). In the latter case the detectors were explicitly modelled in the dose calculation. The commissioned model was used to derive the correction and perturbation factors with respect to a small point in water as suggested by the Alfonso formalism. In MC calculations the design of two detectors was modified in order to minimize or eliminate the corrections needed. The results of this study indicate that a commissioning process using large fields does not lead to an accurate estimation of the source size, even if a 2 × 2 cm(2) field is included. Furthermore, the detector should be explicitly modelled in the calculations. On the output factors, the scintillator W1 needed the smallest correction (+0.6%), followed by the microDiamond (+1.3%). Larger corrections were observed for the microLion (+2.4%) and diode D1V (-2.4%). On the profiles, significant corrections were observed out of the field on the gradient and tail regions. The scintillator needed the smallest corrections (-4%), followed by the microDiamond (-11%), diode D1V (+13%) and microLion (-15%). The major perturbations reported were due to volume averaging and high density materials that surround the active volumes. These effects presented opposite trends in both OF and profiles. By decreasing the radius of the microLion to 0.85 mm we could modify the volume averaging effect in order to achieve a discrepancy less than 1% for OF and 5% for profiles compared to water. Similar results were observed for the diode D1V if the radius was increased to 1 mm.
本研究的目的是得出一套完整的输出因子(OF)和剂量分布的校正因子与扰动因子。对现代小射野探测器进行了研究,包括塑料闪烁体(Exradin W1,SI)、液体电离室(microLion 31018,PTW)、无屏蔽二极管(Exradin D1V,SI)和合成金刚石探测器(microDiamond 60019,PTW)。按照两种调试程序启用了蒙特卡罗(MC)射束模型用于小射野:(1)使用中等大小和适度小的射野(小至2×2 cm²),以及(2)仅使用小射野(0.5×0.5 cm² - 2×2 cm²)。在后一种情况下,探测器在剂量计算中进行了显式建模。启用的模型用于按照阿方索形式主义的建议得出相对于水中一个小点的校正因子与扰动因子。在MC计算中,对两个探测器的设计进行了修改,以尽量减少或消除所需的校正。本研究结果表明,即使包含一个2×2 cm² 的射野,使用大射野的调试过程也无法准确估计源尺寸。此外,探测器应在计算中进行显式建模。在输出因子方面,闪烁体W1所需的校正最小(+0.6%),其次是合成金刚石探测器(+1.3%)。对于液体电离室(+2.4%)和二极管D1V(-2.4%),观察到较大的校正。在剂量分布方面,在射野外的梯度和尾部区域观察到显著的校正。闪烁体所需的校正最小(-4%),其次是合成金刚石探测器(-11%)、二极管D1V(+13%)和液体电离室(-15%)。报告的主要扰动是由于体积平均以及围绕有效体积的高密度材料。这些效应在输出因子和剂量分布中呈现相反的趋势。通过将液体电离室的半径减小到0.85 mm,我们可以改变体积平均效应,以使与水相比,输出因子的差异小于1%,剂量分布的差异小于5%。如果将二极管D1V的半径增加到1 mm,也观察到了类似的结果。