Department of Electronic and Computer Engineering, National Taiwan University of Science and Technology, Taipei 106335, Taiwan.
Graduate Institute of Electro-Optical Engineering, National Taiwan University of Science and Technology, Taipei 106335, Taiwan.
Nanotechnology. 2024 Sep 2;35(46). doi: 10.1088/1361-6528/ad7141.
The study utilized transition metal chalcogenide, molybdenum diselenide (MoSe), for application in the field of bioelectrochemical sensing. The MoSewas combined with carbon nanotubes (CNTs) by chemical vapor deposition to enhance the specific surface area and improve the detection sensitivity. To further increase the contact area between the electrolyte and the electrode, photolithography techniques were employed to fabricate hive-shaped CNTs, thereby enhancing the specific surface area. Next, cholesterol oxidase (ChO) was coated onto the electrode material, creating a cholesterol biosensor. Cyclic voltammetry was utilized to detect the concentration of cholesterol. The experiment involved segmented testing for cholesterol concentrations ranging from 0M to 10 mM. Excellent sensitivity, low detection limits, and high accuracy were achieved. In the cholesterol concentration range of 0M-100M, the experiment achieved the highest sensitivity of 4.44AM⋅cm. Consequently, all data indicated that ChO/MoSe/CNTs functioned as an excellent cholesterol sensor in the study.
该研究利用过渡金属硫属化物、二硒化钼（MoSe）在生物电化学传感领域的应用。通过化学气相沉积将 MoSe 与碳纳米管（CNTs）结合，以提高比表面积并提高检测灵敏度。为了进一步增加电解质与电极之间的接触面积，采用光刻技术制造了蜂巢状 CNTs，从而提高了比表面积。接下来，将胆固醇氧化酶（ChO）涂覆在电极材料上，制成胆固醇生物传感器。利用循环伏安法检测胆固醇的浓度。实验中对胆固醇浓度在 0M 至 10mM 之间进行了分段测试。实验结果表明，该传感器具有出色的灵敏度、低检测限和高精度。在胆固醇浓度为 0M-100M 的范围内，实验实现了最高的灵敏度 4.44AM⋅cm。因此，所有数据表明，在该研究中，ChO/MoSe/CNTs 作为一种优异的胆固醇传感器发挥了作用。
