KAT 故事：Gcn5 和 PCAF 赖氨酸乙酰转移酶在 SAGA 和 ATAC 中的功能。
KAT tales: Functions of Gcn5 and PCAF lysine acetyltransferases in SAGA and ATAC.
机构信息
Department of Epigenetics and Molecular Carcinogenesis, University of Texas M.D. Anderson Cancer, Center for Cancer Epigenetics, University of Texas M.D. Anderson/UTHealth Houston Graduate School of Biomedical Sciences, Houston, Texas, USA.
出版信息
J Biol Chem. 2024 Oct;300(10):107744. doi: 10.1016/j.jbc.2024.107744. Epub 2024 Sep 1.
The Allis group identified Gcn5 as the first transcription-related lysine acetyltransferase in 1996, providing a molecular "missing link" between chromatin organization and gene regulation. This review will focus on functions subsequently identified for Gcn5 and the closely related PCAF protein, in the context of two major complexes, SAGA and ATAC, and how the study of these enzymes informs long standing questions regarding the importance of lysine acetylation.
1996 年，Allis 小组鉴定出 Gcn5 是第一个与转录相关的赖氨酸乙酰转移酶，为染色质结构和基因调控之间提供了一个分子“缺失环节”。本综述将重点介绍随后在两个主要复合物 SAGA 和 ATAC 的背景下鉴定出的 Gcn5 和密切相关的 PCAF 蛋白的功能，以及这些酶的研究如何回答关于赖氨酸乙酰化重要性的长期存在的问题。
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