School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province 611137, PR China.
Translational Chinese Medicine Key Laboratory of Sichuan Province, Sichuan Academy of Chinese Medicine Sciences, Sichuan Institute for Translational Chinese Medicine, Chengdu, Sichuan 610041, P.R. China.
Biochem Pharmacol. 2024 Nov;229:116511. doi: 10.1016/j.bcp.2024.116511. Epub 2024 Aug 31.
Altered metabolism is a hallmark of cancer, and reprogramming of energy metabolism, known as the "Warburg effect", has long been associated with cancer. Cancer cells use the process of glycolysis to quickly manufacture energy from glucose, pyruvic acid, and lactate, which in turn accelerates the growth of cancer and glycolysis becomes a key target for anti-cancer therapies. Recent groundbreaking discoveries regarding long noncoding RNAs (lncRNAs) have opened a new chapter in the mechanism of cancer occurrence. It is widely recognized that lncRNAs regulate energy metabolism through glycolysis in cancer cells. LncRNAs have been demonstrated to engage in several cancer processes such as proliferation, apoptosis, migration, invasion, and chemoresistance, whereas glycolysis is enhanced or inhibited by the dysregulation of lncRNAs. As a result, cancer survival and development are influenced by different signaling pathways. In this review, we summarize the roles of lncRNAs in a variety of cancers and describe the mechanisms underlying their role in glycolysis. Additionally, the predictive potential of glycolysis and lncRNAs in cancer therapy is discussed.
代谢改变是癌症的一个标志，能量代谢的重编程，即“Warburg 效应”，长期以来一直与癌症有关。癌细胞利用糖酵解过程，从葡萄糖、丙酮酸和乳酸中快速制造能量，这反过来又加速了癌症的生长，糖酵解成为抗癌疗法的一个关键靶点。最近关于长链非编码 RNA（lncRNA）的突破性发现为癌症发生机制开辟了一个新篇章。人们普遍认识到，lncRNA 通过癌细胞中的糖酵解来调节能量代谢。lncRNA 已被证明参与了几种癌症过程，如增殖、凋亡、迁移、侵袭和化疗耐药性，而 lncRNA 的失调则增强或抑制糖酵解。因此，不同的信号通路影响着癌症的存活和发展。在这篇综述中，我们总结了 lncRNA 在多种癌症中的作用，并描述了它们在糖酵解中作用的机制。此外，还讨论了糖酵解和 lncRNA 在癌症治疗中的预测潜力。
