Department of Nutrition and Food Hygiene, School of Public Health, Medical College of Soochow University, Suzhou 215123, China; Department of clinical laboratory Center, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
School of Clinical Medicine, Medical College of Soochow University, Suzhou 215123, China.
Biomed Pharmacother. 2024 Jul;176:116831. doi: 10.1016/j.biopha.2024.116831. Epub 2024 Jun 1.
Metabolic reprogramming plays critical roles in the development and progression of tumor by providing cancer cells with a sufficient supply of nutrients and other factors needed for fast-proliferating. Emerging evidence indicates that long noncoding RNAs (lncRNAs) are involved in the initiation of metastasis via regulating the metabolic reprogramming in various cancers. In this paper, we aim to summarize that lncRNAs could participate in intracellular nutrient metabolism including glucose, amino acid, lipid, and nucleotide, regardless of whether lncRNAs have tumor-promoting or tumor-suppressor function. Meanwhile, modulation of lncRNAs in glucose metabolic enzymes in glycolysis, pentose phosphate pathway and tricarboxylic acid cycle (TCA) in cancer is reviewed. We also discuss therapeutic strategies targeted at interfering with enzyme activity to decrease the utilization of glucoses, amino acid, nucleotide acid and lipid in tumor cells. This review focuses on our current understanding of lncRNAs participating in cancer cell metabolic reprogramming, paving the way for further investigation into the combination of such approaches with existing anti-cancer therapies.
代谢重编程通过为癌细胞提供快速增殖所需的充足营养物质和其他因素，在肿瘤的发生和发展中起着关键作用。新出现的证据表明，长链非编码 RNA（lncRNA）通过调节各种癌症中的代谢重编程，参与转移的发生。在本文中，我们旨在总结 lncRNA 可以参与包括葡萄糖、氨基酸、脂质和核苷酸在内的细胞内营养物质代谢，而不论 lncRNA 是否具有促进肿瘤或抑制肿瘤的功能。同时，综述了 lncRNA 在糖酵解、磷酸戊糖途径和三羧酸循环（TCA）中葡萄糖代谢酶中的调节作用。我们还讨论了针对干扰酶活性以减少肿瘤细胞中葡萄糖、氨基酸、核苷酸和脂质利用的治疗策略。本综述重点介绍了我们目前对 lncRNA 参与癌细胞代谢重编程的理解，为进一步研究将这些方法与现有的抗癌疗法相结合铺平了道路。
