来自海洋真菌青霉属ZYX-Z-718的抗菌吲哚二萜生物碱
Antibacterial Indole-Diterpenoid Alkaloids from the Marine Fungus Penicillium sp. ZYX-Z-718.
作者信息
Yang Li, Quan Miao-Miao, Ma Qing-Yun, Xie Qing-Yi, Gai Cui-Juan, Dai Hao-Fu, Hao Yu-E, Zhao You-Xing
机构信息
Haikou Key Laboratory for Research and Utilization of Tropical Natural Products & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, 571101, China.
Department of Public Health Laboratory Sciences, School of Public Health, Heng-yang Medical School, University of South China, Hengyang, Hunan, 421001, China.
出版信息
Chem Biodivers. 2024 Dec;21(12):e202401871. doi: 10.1002/cbdv.202401871. Epub 2024 Oct 26.
Two new indole-diterpenoids, penpaxilloids F and G (1 and 2), along with 11 known analogues (3-13), were isolated from the marine fungus Penicillium sp. ZYX-Z-718. The structures of the new compounds were identified by extensive spectroscopic analyses including HR-ESI-MS, UV, and NMR, as well as theoretical NMR chemical shifts and ECD calculations. Compounds 6 and 10 showed antibacterial activity against Gram-positive bacteria including Staphylococcus aureus, Bacillus subtilis, and MRSA with MIC values ranging from 16.0-32.0 μg/mL.
从海洋真菌青霉菌ZYX-Z-718中分离出两种新的吲哚-二萜类化合物，青霉帕西洛类化合物F和G（1和2），以及11种已知类似物（3-13）。通过包括高分辨电喷雾电离质谱（HR-ESI-MS）、紫外光谱（UV）和核磁共振（NMR）在内的广泛光谱分析，以及理论核磁共振化学位移和电子圆二色光谱（ECD）计算，确定了新化合物的结构。化合物6和10对包括金黄色葡萄球菌、枯草芽孢杆菌和耐甲氧西林金黄色葡萄球菌（MRSA）在内的革兰氏阳性菌显示出抗菌活性，其最低抑菌浓度（MIC）值范围为16.0 - 32.0μg/mL。
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