Huang Zediao, Wu Di, Liu Xueqiong, Liu Qingpei, Han Xiaole, Wang Wenjing, Yang Xiaolong
School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, P.R. China.
Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education & Hubei Key Laboratory of Catalysis and Materials Science, South-Central Minzu University, Wuhan, P. R. China.
Nat Prod Res. 2025 Mar;39(5):1156-1165. doi: 10.1080/14786419.2023.2297853. Epub 2024 Feb 1.
Three undescribed indole alkaloids, fusarindoles F and G ( and ), and chlamydosporin B (), together with five known compounds (-) were isolated from . Their structures were elucidated based on NMR, UV, HRESIMS, and ECD calculation. Fusarindole F () own unusual asymmetric bis-indole structure. Compounds , , exhibited moderate antibacterial activity against methicillin-resistant with a MIC value of 12.5 μg/mL. According to molecular docking experiment, the target proteins of compound against methicillin-resistant may be ELANE, MAOB and STAT3.
从[具体来源]中分离出三种未描述的吲哚生物碱，即镰刀菌素F和G（[具体结构简式]）以及枝孢菌素B（[具体结构简式]），同时还分离出了五种已知化合物（[具体结构简式]）。基于核磁共振（NMR）、紫外光谱（UV）、高分辨电喷雾电离质谱（HRESIMS）和电子圆二色光谱（ECD）计算对它们的结构进行了阐明。镰刀菌素F（[具体结构简式]）具有不寻常的不对称双吲哚结构。化合物[具体编号]、[具体编号]、[具体编号]对耐甲氧西林金黄色葡萄球菌表现出中等抗菌活性，最低抑菌浓度（MIC）值为12.5μg/mL。根据分子对接实验，化合物[具体编号]针对耐甲氧西林金黄色葡萄球菌的靶蛋白可能是弹性蛋白酶（ELANE）、单胺氧化酶B（MAOB）和信号转导和转录激活因子3（STAT3）。
