Himalayan School of Biosciences, Swami Rama Himalayan University, Swami Ram Nagar, Jollygrant, Dehradun, Uttarakhand, India, 248140.
Department of Robotics and Mechatronics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Dalseong-gun, Daegu, 42988, South Korea.
Sci Rep. 2024 Sep 2;14(1):20404. doi: 10.1038/s41598-024-71042-w.
The research introduces a novel method for creating drug-loaded hydrogel beads that target anti-aging, anti-oxidative, and anti-inflammatory effects, addressing the interconnected processes underlying various pathological conditions. The study focuses on the development of hydrogel beads containing anti-aging compounds, antioxidants, and anti-inflammatory drugs to effectively mitigate various processes. The synthesis, characterization and in vitro evaluations, and potential applications of these multifunctional hydrogel beads are discussed. A polymeric alginate-orange peel extract (1:1) hydrogel was synthesized for encapsulating fish oil. Beads prepared with variable fish oil concentrations (0.1, 0.3, and 0.5 ml) were characterized, showing no significant decrease in size i.e., 0.5 mm and a reduction in pore size from 23 to 12 µm. Encapsulation efficiency reached up to 98% within 2 min, with controlled release achieved upto 45 to 120 min with increasing oil concentration, indicating potential for sustained delivery. Fourier-transform infrared spectroscopy confirmed successful encapsulation by revealing peak shifting, interaction between constituents. In vitro degradation studies showed the hydrogel's biodegradability improved from 30 to 120 min, alongside anti-inflammatory, anti-oxidative, anti-collagenase and anti-elastase activities, cell proliferation rate enhanced after entrapping fish oil. In conclusion, the synthesized hydrogel beads are a promising drug delivery vehicle because they provide stable and effective oil encapsulation with controlled release for notable anti-aging and regenerative potential. Targeted delivery for inflammatory and oxidative stress-related illnesses is one set of potential uses. Further research may optimize this system for broader applications in drug delivery and tissue engineering.
该研究介绍了一种新颖的方法，用于创建靶向抗衰老、抗氧化和抗炎作用的载药水凝胶珠，解决了各种病理条件下相互关联的过程。该研究侧重于开发含有抗衰老化合物、抗氧化剂和抗炎药物的水凝胶珠，以有效减轻各种过程。讨论了这些多功能水凝胶珠的合成、表征和体外评估以及潜在应用。合成了一种用于包封鱼油的藻酸钠-橙皮提取物（1:1）聚合物水凝胶。用不同浓度的鱼油（0.1、0.3 和 0.5ml）制备的珠子进行了表征，发现其粒径没有明显减小（即 0.5mm），孔径从 23 减小到 12µm。包封效率在 2 分钟内高达 98%，随着油浓度的增加，控制释放可达 45 至 120 分钟，表明具有持续释放的潜力。傅里叶变换红外光谱证实了成功的封装，因为它显示了峰的移动和成分之间的相互作用。体外降解研究表明，水凝胶的生物降解性从 30 分钟提高到 120 分钟，同时具有抗炎、抗氧化、抗胶原酶和抗弹性蛋白酶活性，包封鱼油后细胞增殖率提高。总之，合成的水凝胶珠是一种有前途的药物输送载体，因为它们提供了稳定有效的油包封和控制释放，具有显著的抗衰老和再生潜力。靶向治疗与炎症和氧化应激相关的疾病是其潜在用途之一。进一步的研究可能会优化该系统，以更广泛地应用于药物输送和组织工程。
