Department of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, 28 Zyty Str., 65-417 Zielona Gora, Poland.
Nutrients. 2021 Oct 21;13(11):3696. doi: 10.3390/nu13113696.
One of the latest theories on ageing focuses on immune response, and considers the activation of subclinical and chronic inflammation. The study was designed to explain whether anti-inflammatory diet and lifestyle exercise affect an inflammatory profile in the Polish elderly population. Sixty individuals (80.2 ± 7.9 years) were allocated to a low-grade inflammation (LGI = 33) or high-grade inflammation (HGI = 27) group, based on C-reactive protein concentration (<3 or ≥3 mg/L) as a conventional marker of systemic inflammation. Diet analysis focused on vitamins D, C, E, A, β-carotene, n-3 and n-6 PUFA using single 24-h dietary recall. LGI demonstrated a lower n-6/n-3 PUFA but higher vitamin D intake than HGI. Physical performance based on 6-min walk test (6MWT) classified the elderly as physically inactive, whereby LGI demonstrated a significantly higher gait speed (1.09 ± 0.26 m/s) than HGI (0.72 ± 0.28 m/s). Circulating interleukins IL-1β, IL-6, IL-13, TNFα and cfDNA demonstrated high concentrations in the elderly with low 6MWT, confirming an impairment of physical performance by persistent systemic inflammation. These findings reveal that increased intake of anti-inflammatory diet ingredients and physical activity sustained throughout life attenuate progression of inflammaging in the elderly and indicate potential therapeutic strategies to counteract pathophysiological effects of ageing.
衰老的最新理论之一集中在免疫反应上，并认为亚临床和慢性炎症的激活。这项研究旨在解释抗炎饮食和生活方式锻炼是否会影响波兰老年人群的炎症特征。60 名个体（80.2±7.9 岁）根据 C 反应蛋白浓度（<3 或≥3mg/L）分为低水平炎症（LGI=33）或高水平炎症（HGI=27）组，作为全身性炎症的常规标志物。饮食分析侧重于维生素 D、C、E、A、β-胡萝卜素、n-3 和 n-6PUFA，使用单一 24 小时膳食回忆法。LGI 组 n-6/n-3PUFA 水平较低，但维生素 D 摄入量较高。基于 6 分钟步行测试（6MWT）的身体表现将老年人归类为身体不活跃，LGI 组的步速（1.09±0.26m/s）明显高于 HGI 组（0.72±0.28m/s）。循环白细胞介素 IL-1β、IL-6、IL-13、TNFα 和 cfDNA 在低 6MWT 的老年人中表现出高浓度，证实持续的全身炎症会损害身体表现。这些发现表明，增加抗炎饮食成分的摄入和终生的身体活动可以减缓老年人炎症老化的进展，并指出了潜在的治疗策略来对抗衰老的病理生理影响。
