Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary, HMRB 162, Health Sciences Centre, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada.
Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada.
Mol Brain. 2024 Sep 2;17(1):64. doi: 10.1186/s13041-024-01138-x.
Aerobic exercise has many effects on brain function, particularly at the hippocampus. Exercise has been shown to increase the rate of adult neurogenesis within the dentate gyrus and decrease the density of perineuronal nets in area CA1. The relationship between the rate of neurogenesis and the density of perineuronal nets in CA1 is robust; however, these studies only ever examined these effects across longer time scales, with running manipulations of 4 weeks or longer. With such long periods of manipulation, the precise temporal nature of the relationship between running-induced neurogenesis and reduced perineuronal net density in CA1 is unknown. Here, we provided male and female mice with home cage access to running wheels for 0, 1, 2, or 4 weeks and quantified hippocampal neurogenesis and CA1 perineuronal net density. In doing so, we observed a 2-week delay period prior to the increase in neurogenesis, which coincided with the same delay prior to decreased CA1 perineuronal net density. These results highlight the closely linked temporal relationship between running-induced neurogenesis and decreased perineuronal net expression in CA1.
有氧运动对大脑功能有很多影响，特别是在海马体。研究表明，运动可以增加齿状回内成体神经发生的速度，并减少 CA1 区周围神经网的密度。神经发生速度和 CA1 区周围神经网密度之间的关系是稳健的；然而，这些研究只在更长的时间尺度上考察了这些影响，跑步干预时间为 4 周或更长。在如此长的干预时间内，跑步诱导的神经发生和 CA1 区周围神经网密度降低之间的精确时间关系尚不清楚。在这里，我们让雄性和雌性小鼠在其笼内自由使用跑轮，时间分别为 0、1、2 或 4 周，并对海马体神经发生和 CA1 区周围神经网密度进行了量化。通过这样做，我们观察到神经发生增加之前有一个 2 周的延迟期，这与 CA1 区周围神经网密度降低的延迟期相同。这些结果突出了跑步诱导的神经发生和 CA1 区周围神经网表达降低之间紧密的时间关系。
