Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Breast Cancer Res. 2024 Sep 2;26(1):127. doi: 10.1186/s13058-024-01885-8.
Ductal carcinoma in situ (DCIS) is a non-obligate precursor to invasive breast cancer (IBC). Studies have indicated differences in DCIS outcome based on race or ethnicity, but molecular differences have not been investigated.
We examined the molecular profile of DCIS by self-reported race (SRR) and outcome groups in Black (n = 99) and White (n = 191) women in a large DCIS case-control cohort study with longitudinal follow up.
Gene expression and pathway analyses suggested that different genes and pathways are involved in diagnosis and ipsilateral breast outcome (DCIS or IBC) after DCIS treatment in White versus Black women. We identified differences in ER and HER2 expression, tumor microenvironment composition, and copy number variations by SRR and outcome groups.
Our results suggest that different molecular mechanisms drive initiation and subsequent ipsilateral breast events in Black versus White women.
导管原位癌（DCIS）是非浸润性乳腺癌（IBC）的强制性前体。研究表明，基于种族或民族的 DCIS 结果存在差异，但尚未研究分子差异。
我们通过自我报告的种族（SRR）和黑人（n=99）和白人（n=191）女性在大型 DCIS 病例对照队列研究中的结果组，检查了 DCIS 的分子特征，该研究具有纵向随访。
基因表达和途径分析表明，在 DCIS 治疗后，白人女性与黑人女性在诊断和同侧乳房结局（DCIS 或 IBC）中涉及不同的基因和途径。我们通过 SRR 和结果组鉴定了 ER 和 HER2 表达、肿瘤微环境组成和拷贝数变异的差异。
我们的结果表明，不同的分子机制在黑人女性与白人女性中驱动着起始和随后的同侧乳房事件。
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